論文 - 詳細
| RRC ID | 82495 |
|---|---|
| 著者 | Zhang N, Liu C, Jin L, Zhang R, Wang T, Wang Q, Chen J, Yang F, Siebert HC, Zheng X. |
| タイトル | Ketogenic Diet Elicits Antitumor Properties through Inducing Oxidative Stress, Inhibiting MMP-9 Expression, and Rebalancing M1/M2 Tumor-Associated Macrophage Phenotype in a Mouse Model of Colon Cancer. |
| ジャーナル | J Agric Food Chem |
| Abstract |
Many advanced cancers are characterized by metabolic disorders. A dietary therapeutic strategy was proposed to inhibit tumor growth through administration of low-carbohydrate, average-protein, and high-fat diet, which is also known as ketogenic diet (KD). In vivo antitumor efficacy of KD on transplanted CT26+ tumor cells in BALB/c mice was investigated. The results showed that the KD group had significantly higher blood β-hydroxybutyrate and lower blood glucose levels when compared with the normal diet group. Meanwhile, KD increased intratumor oxidative stress, and TUNEL staining showed KD-induced apoptosis against tumor cells. Interestingly, the distribution of CD16/32+ and iNOS+ M1 tumor-associated macrophages (TAMs) increased in the KD-treated group, with concomitantly less arginase-1+ M2 TAMs. Moreover, KD treatment downregulated the protein expression of matrix metalloproteinase-9 in CT26+ tumor-bearing mice. Western blot analysis demonstrated that the expression levels of HDAC3/PKM2/NF-κB 65/p-Stat3 proteins were reduced in the KD-treated group. Taken together, our results indicated that KD can prevent the progression of colon tumor via inducing intratumor oxidative stress, inhibiting the expression of the MMP-9, and enhancing M2 to M1 TAM polarization. A novel potential mechanism was identified that KD can prevent the progression of colon cancer by regulating the expression of HDAC3/PKM2/NF-κB65/p-Stat3 axis. |
| 巻・号 | 68(40) |
| ページ | 11182-11196 |
| 公開日 | 2020-10-7 |
| DOI | 10.1021/acs.jafc.0c04041 |
| PMID | 32786841 |
| MeSH | Animals Cell Line, Tumor Colonic Neoplasms / diet therapy* Colonic Neoplasms / genetics Colonic Neoplasms / immunology* Diet, Ketogenic* Disease Models, Animal Humans Male Matrix Metalloproteinase 9 / genetics Matrix Metalloproteinase 9 / immunology* Mice Mice, Inbred BALB C NF-kappa B / genetics NF-kappa B / immunology Oxidative Stress* STAT3 Transcription Factor / genetics STAT3 Transcription Factor / immunology Tumor-Associated Macrophages / immunology* |
| IF | 4.192 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 62 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Colon-26(RCB2657) |