| RRC ID |
82504
|
| Author |
Karki SS, Das U, Balzarini J, De Clercq E, Sakagami H, Uesawa Y, Roayapalley PK, Dimmock JR.
|
| Title |
Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones?
|
| Journal |
Medicines (Basel)
|
| Abstract |
Background: A series of 3,5-benzylidene-4-piperidones, 1a-n, were prepared to evaluate the hypothesis that the placement of different groups in the ortho-location of the aryl rings led to compounds with greater cytotoxic potencies than structural analogs. Methods: The bioevaluation of 1a-n was undertaken using human Molt/4C8 and CEM cells as well as murine L1210 cells. Correlations were sought between the interplanar angles θA and θB and the cytotoxic potencies. A QSAR analysis was also undertaken. In order to evaluate whether these compounds demonstrated greater toxicity to neoplasms than non-malignant cells, 1a-n were evaluated against HSC-2, HSC-3, HSC-4 and HL60 neoplasms as well as non-malignant HGF, HPC and HPLF cells. Results: A positive correlation was noted between the interplanar angle θA of one of the aryl rings and the adjacent olefinic linkage with IC50 values in the Molt4/C8 screens. The QSAR analysis revealed a positive correlation between the Hansch pi (π) value of the aryl substituents and the IC50 values of the compounds towards the Molt4/C8 and CEM cells. The dienones in series 1 demonstrated higher tumor-selective toxicity towards HSC-2, HSC-3, HSC-4 and HL-60 neoplasms than HGF, HPC and HPLF cells. Conclusions: The bioevaluations revealed some support for greater cytotoxic potencies to be displayed by compounds having ortho-substituents.
|
| Volume |
11(8)
|
| Published |
2024-10-30
|
| DOI |
10.3390/medicines11080019
|
| PII |
medicines11080019
|
| PMID |
39584969
|
| PMC |
PMC11587156
|
| Resource |
| Human and Animal Cells |
HSC-2(RCB1945)
HSC-3(RCB1975)
HSC-4(RCB1902)
HL-60(RCB3683) |
