論文 - 詳細
| RRC ID | 82515 |
|---|---|
| 著者 | Yin X, Liu Y, Zeb R, Chen F, Chen H, Wang KJ. |
| タイトル | The intergenerational toxic effects on offspring of medaka fish Oryzias melastigma from parental benzo[a]pyrene exposure via interference of the circadian rhythm. |
| ジャーナル | Environ Pollut |
| Abstract |
Benzo[a]pyrene (BaP), a widely existed polycyclic aromatic hydrocarbon pollutant in aquatic environment, has toxic effects on marine animals and their generations, but the intergenerational immunotoxic mechanism underlying has not been clearly understood. In the study, the offspring of marine medaka (oryzias melastigma) which were exposed to 0.5 μg L-1 BaP suffered from circadian rhythm oscillation disorders and severe DNA damage. Many clock-associated genes like per1 were significantly modulated in offspring, both per1 and p53 were significantly inhibited that altered the progression of cell cycle and inhibited DNA repair, which possibly resulted in the increased mortality of offspring. The hypermethylation of the per1 promotor and abnormal levels of N6-methyladenosine (m6A) suggested that the underlying mechanism was probably related to the epigenetic modification. Moreover, the offspring from paternal BaP exposure had more severe DNA damage and a higher degree of hypermethylation than those from maternal exposure. F1 larvae from BaP-exposed parents were more sensitive to BaP exposure, showing that the expression of immune and metabolism-related genes were significantly up-regulated. Taken together, the parental toxicity induced by BaP could be passed to F1 generation and the mechanism underlying was probably associated with a characteristic circadian rhythm disorder. |
| 巻・号 | 267 |
| ページ | 115437 |
| 公開日 | 2020-12-1 |
| DOI | 10.1016/j.envpol.2020.115437 |
| PII | S0269-7491(20)36125-X |
| PMID | 32866872 |
| MeSH | Animals Benzo(a)pyrene / toxicity Circadian Rhythm Environmental Pollutants* Female Humans Male Oryzias* Water Pollutants, Chemical* / analysis Water Pollutants, Chemical* / toxicity |
| IF | 6.793 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | DIT29(RCB2945) |