Reference - Detail
| RRC ID | 82552 |
|---|---|
| Author | Mass S, Cohen H, Podicheti R, Rusch DB, Gerlic M, Ushijima B, van Kessel JC, Bosis E, Salomon D. |
| Title | The coral pathogen Vibrio coralliilyticus uses a T6SS to secrete a group of novel anti-eukaryotic effectors that contribute to virulence. |
| Journal | PLoS Biol |
| Abstract |
Vibrio coralliilyticus is a pathogen of coral and shellfish, leading to devastating economic and ecological consequences worldwide. Although rising ocean temperatures correlate with increased V. coralliilyticus pathogenicity, the specific molecular mechanisms and determinants contributing to virulence remain poorly understood. Here, we systematically analyzed the type VI secretion system (T6SS), a contact-dependent toxin delivery apparatus, in V. coralliilyticus. We identified 2 omnipresent T6SSs that are activated at temperatures in which V. coralliilyticus becomes virulent; T6SS1 is an antibacterial system mediating interbacterial competition, whereas T6SS2 mediates anti-eukaryotic toxicity and contributes to mortality during infection of an aquatic model organism, Artemia salina. Using comparative proteomics, we identified the T6SS1 and T6SS2 toxin arsenals of 3 V. coralliilyticus strains with distinct disease etiologies. Remarkably, T6SS2 secretes at least 9 novel anti-eukaryotic toxins comprising core and accessory repertoires. We propose that T6SSs differently contribute to V. coralliilyticus's virulence: T6SS2 plays a direct role by targeting the host, while T6SS1 plays an indirect role by eliminating competitors. |
| Volume | 22(9) |
| Pages | e3002734 |
| Published | 2024-9-1 |
| DOI | 10.1371/journal.pbio.3002734 |
| PII | PBIOLOGY-D-24-00845 |
| PMID | 39226241 |
| PMC | PMC11371242 |
| MeSH | Animals Anthozoa* / microbiology Artemia / microbiology Bacterial Proteins / genetics Bacterial Proteins / metabolism Bacterial Toxins / genetics Bacterial Toxins / metabolism Proteomics / methods Type VI Secretion Systems* / genetics Type VI Secretion Systems* / metabolism Vibrio* / genetics Vibrio* / metabolism Vibrio* / pathogenicity Vibrio Infections / microbiology Virulence Virulence Factors / metabolism |
| IF | 7.076 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 15 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pGML10 (RDB01957) |