論文 - 詳細
| RRC ID | 82589 |
|---|---|
| 著者 | Beaubois R, Cheslet J, Duenki T, De Venuto G, Carè M, Khoyratee F, Chiappalone M, Branchereau P, Ikeuchi Y, Levi T. |
| タイトル | BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network. |
| ジャーナル | Nat Commun |
| Abstract |
Characterization and modeling of biological neural networks has emerged as a field driving significant advancements in our understanding of brain function and related pathologies. As of today, pharmacological treatments for neurological disorders remain limited, pushing the exploration of promising alternative approaches such as electroceutics. Recent research in bioelectronics and neuromorphic engineering have fostered the development of the new generation of neuroprostheses for brain repair. However, achieving their full potential necessitates a deeper understanding of biohybrid interaction. In this study, we present a novel real-time, biomimetic, cost-effective and user-friendly neural network capable of real-time emulation for biohybrid experiments. Our system facilitates the investigation and replication of biophysically detailed neural network dynamics while prioritizing cost-efficiency, flexibility and ease of use. We showcase the feasibility of conducting biohybrid experiments using standard biophysical interfaces and a variety of biological cells as well as real-time emulation of diverse network configurations. We envision our system as a crucial step towards the development of neuromorphic-based neuroprostheses for bioelectrical therapeutics, enabling seamless communication with biological networks on a comparable timescale. Its embedded real-time functionality enhances practicality and accessibility, amplifying its potential for real-world applications in biohybrid experiments. |
| 巻・号 | 15(1) |
| ページ | 5142 |
| 公開日 | 2024-6-20 |
| DOI | 10.1038/s41467-024-48905-x |
| PII | 10.1038/s41467-024-48905-x |
| PMID | 38902236 |
| PMC | PMC11190274 |
| MeSH | Action Potentials / physiology Animals Biomimetics* / methods Humans Models, Neurological Nerve Net / physiology Nervous System Diseases* Neural Networks, Computer* Neurons / metabolism Neurons / physiology |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 34 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 409B2(HPS0076) |