| RRC ID |
82635
|
| 著者 |
Deminami M, Hashimoto M, Takahashi H, Harada N, Minami Y, Kitakaze T, Masuda W, Takenaka S, Inui H, Yamaji R.
|
| タイトル |
Androgens suppress the sialyltransferases ST3GAL1 and ST3GAL4 and modulate mucin 10 glycosylation in the submandibular gland, related to sex differences in commensal microbiota composition in mice.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Sex differences exist in the commensal microbiota that impact on multiple physiological processes in the host. Here, we examined the mechanism by which the sex differences are formed. In addition to the epithelial ductal cell, the acinar cell mass in the submandibular gland was associated with androgen-androgen receptor (AR) signaling. There was a sex difference in the formation of submandibular mucin 10 (MUC10) in SDS-PAGE. Neuraminidase treatment, which hydrolyzes terminal sialic acid, influenced the mobility shift of MUC10. Androgen-AR signaling negatively regulated St3 β-galactoside α-2,3-sialyltransferase 1 (St3gal1) and St3gal4 in the submandibular gland. There was a trend and significant sex differences in α-diversity (Shannon, p=0.09) and β-diversity (unweighted UniFrac) in oral microbiota composition, respectively. Some female-preferring bacteria including Akkermansia muciniphila can assimilate mucin by degrading terminal sialic acids. Our results indicate that androgen-AR signaling suppresses ST3GAL1 and ST3GAL4, which can influence sex differences in commensal microbiota composition.
|
| 公開日 |
2024-11-21
|
| DOI |
10.1093/bbb/zbae175
|
| PII |
7906610
|
| PMID |
39572079
|
| MeSH |
Androgens* / pharmacology
Animals
Female
Glycosylation / drug effects
Male
Mice
Mice, Inbred C57BL
Microbiota* / drug effects
Mucins* / metabolism
Neuraminidase / metabolism
Receptors, Androgen / metabolism
Sex Characteristics*
Sialyltransferases* / antagonists & inhibitors
Sialyltransferases* / metabolism
Submandibular Gland* / drug effects
Submandibular Gland* / metabolism
Submandibular Gland* / microbiology
beta-Galactoside alpha-2,3-Sialyltransferase
|
| IF |
1.516
|
| リソース情報 |
| ヒト・動物細胞 |
LNCap.FGC(RCB2144) |
| 実験動物マウス |
RBRC01828 |
