論文 - 詳細
| RRC ID | 82669 |
|---|---|
| 著者 | Yamashita Y, Hayashi M, Liu A, Sasaki F, Tsuchiya Y, Takayanagi H, Saito M, Nakashima T. |
| タイトル | Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation. |
| ジャーナル | Nat Commun |
| Abstract |
Bone remodeling maintains the robustness of the bone tissue by balancing bone resorption by osteoclasts and bone formation by osteoblasts. Although these cells together play a crucial role in bone remodeling, only a few reports are available on the common factors involved in the differentiation of the two types of cells. Here, we show family with sequence similarity 102 member A (Fam102a) as a bone-remodeling factor that positively regulates both osteoclast and osteoblast differentiation. Fam102a regulates osteoblast differentiation by controlling recombination signal binding protein for immunoglobulin κ J region-like (Rbpjl). The Fam102a-Rbpjl axis promotes the nuclear translocation of transcription factors and enhances the expression of Osterix, a transcription factor essential for osteoblast differentiation. The deletion of Fam102a or a functional mutation in Rbpjl leads to osteopenia accompanied by reduced osteoblastic bone formation. Thus, the Fam102a-Rbpjl axis plays an important role in osteoblasts and this finding provides insights into bone remodeling. |
| 巻・号 | 16(1) |
| ページ | 9 |
| 公開日 | 2025-1-2 |
| DOI | 10.1038/s41467-024-55451-z |
| PII | 10.1038/s41467-024-55451-z |
| PMID | 39747056 |
| PMC | PMC11695619 |
| MeSH | Animals Bone Diseases, Metabolic / genetics Bone Diseases, Metabolic / metabolism Bone Diseases, Metabolic / pathology Bone Remodeling / genetics Cell Differentiation* Core Binding Factor Alpha 1 Subunit* / genetics Core Binding Factor Alpha 1 Subunit* / metabolism Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein / genetics Immunoglobulin J Recombination Signal Sequence-Binding Protein / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Osteoblasts* / metabolism Osteoclasts* / cytology Osteoclasts* / metabolism Osteogenesis* / genetics Sp7 Transcription Factor* / genetics Sp7 Transcription Factor* / metabolism Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |
| 遺伝子材料 | B6N Mouse BAC clone B6Ng01-148B24 B6Ng01-144H14 |