RRC ID 82669
Author Yamashita Y, Hayashi M, Liu A, Sasaki F, Tsuchiya Y, Takayanagi H, Saito M, Nakashima T.
Title Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation.
Journal Nat Commun
Abstract Bone remodeling maintains the robustness of the bone tissue by balancing bone resorption by osteoclasts and bone formation by osteoblasts. Although these cells together play a crucial role in bone remodeling, only a few reports are available on the common factors involved in the differentiation of the two types of cells. Here, we show family with sequence similarity 102 member A (Fam102a) as a bone-remodeling factor that positively regulates both osteoclast and osteoblast differentiation. Fam102a regulates osteoblast differentiation by controlling recombination signal binding protein for immunoglobulin κ J region-like (Rbpjl). The Fam102a-Rbpjl axis promotes the nuclear translocation of transcription factors and enhances the expression of Osterix, a transcription factor essential for osteoblast differentiation. The deletion of Fam102a or a functional mutation in Rbpjl leads to osteopenia accompanied by reduced osteoblastic bone formation. Thus, the Fam102a-Rbpjl axis plays an important role in osteoblasts and this finding provides insights into bone remodeling.
Volume 16(1)
Pages 9
Published 2025-1-2
DOI 10.1038/s41467-024-55451-z
PII 10.1038/s41467-024-55451-z
PMID 39747056
PMC PMC11695619
MeSH Animals Bone Diseases, Metabolic / genetics Bone Diseases, Metabolic / metabolism Bone Diseases, Metabolic / pathology Bone Remodeling / genetics Cell Differentiation* Core Binding Factor Alpha 1 Subunit* / genetics Core Binding Factor Alpha 1 Subunit* / metabolism Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein / genetics Immunoglobulin J Recombination Signal Sequence-Binding Protein / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Osteoblasts* / metabolism Osteoclasts* / cytology Osteoclasts* / metabolism Osteogenesis* / genetics Sp7 Transcription Factor* / genetics Sp7 Transcription Factor* / metabolism Transcription Factors / genetics Transcription Factors / metabolism
Resource
Human and Animal Cells MC3T3-E1(RCB1126)