| RRC ID |
82669
|
| Author |
Yamashita Y, Hayashi M, Liu A, Sasaki F, Tsuchiya Y, Takayanagi H, Saito M, Nakashima T.
|
| Title |
Fam102a translocates Runx2 and Rbpjl to facilitate Osterix expression and bone formation.
|
| Journal |
Nat Commun
|
| Abstract |
Bone remodeling maintains the robustness of the bone tissue by balancing bone resorption by osteoclasts and bone formation by osteoblasts. Although these cells together play a crucial role in bone remodeling, only a few reports are available on the common factors involved in the differentiation of the two types of cells. Here, we show family with sequence similarity 102 member A (Fam102a) as a bone-remodeling factor that positively regulates both osteoclast and osteoblast differentiation. Fam102a regulates osteoblast differentiation by controlling recombination signal binding protein for immunoglobulin κ J region-like (Rbpjl). The Fam102a-Rbpjl axis promotes the nuclear translocation of transcription factors and enhances the expression of Osterix, a transcription factor essential for osteoblast differentiation. The deletion of Fam102a or a functional mutation in Rbpjl leads to osteopenia accompanied by reduced osteoblastic bone formation. Thus, the Fam102a-Rbpjl axis plays an important role in osteoblasts and this finding provides insights into bone remodeling.
|
| Volume |
16(1)
|
| Pages |
9
|
| Published |
2025-1-2
|
| DOI |
10.1038/s41467-024-55451-z
|
| PII |
10.1038/s41467-024-55451-z
|
| PMID |
39747056
|
| PMC |
PMC11695619
|
| MeSH |
Animals
Bone Diseases, Metabolic / genetics
Bone Diseases, Metabolic / metabolism
Bone Diseases, Metabolic / pathology
Bone Remodeling / genetics
Cell Differentiation*
Core Binding Factor Alpha 1 Subunit* / genetics
Core Binding Factor Alpha 1 Subunit* / metabolism
Humans
Immunoglobulin J Recombination Signal Sequence-Binding Protein / genetics
Immunoglobulin J Recombination Signal Sequence-Binding Protein / metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Osteoblasts* / metabolism
Osteoclasts* / cytology
Osteoclasts* / metabolism
Osteogenesis* / genetics
Sp7 Transcription Factor* / genetics
Sp7 Transcription Factor* / metabolism
Transcription Factors / genetics
Transcription Factors / metabolism
|
| IF |
12.121
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
| DNA material |
B6N Mouse BAC clone
B6Ng01-148B24
B6Ng01-144H14 |
