論文 - 詳細
| RRC ID | 82705 |
|---|---|
| 著者 | Wu L, Lai L, Wu W, Wang Y, Mo G, Kobayashi Y, Ogo N, Koyama H. |
| タイトル | Chemical genetics analysis suggests the involvement of Aurora kinase and MAPKs in aluminum-induced malate secretion in Arabidopsis. |
| ジャーナル | J Plant Res |
| Abstract |
Chemical genetics is a multidisciplinary research method. In this study, it is used to screen compounds that promote aluminum-induced malate secretion in Arabidopsis thaliana. Inhibition of p38 mitogen-activated protein kinase (p38 MAPK; LY2228820) significantly increased the transcription of Arabidopsis thaliana aluminum-activated malate transporter 1 (AtALMT1) and sensitive to proton rhizotoxicity 1 (STOP1)-regulated genes, multidrug and toxic compound extrusion and aluminum sensitive 3, but not AtSTOP1 and the Al-biomarker genes At3g28510, At5g13320, suggesting that LY2228820 increased the early expression of STOP1-regulated genes without affecting AtSTOP1 expression. Inhibition of p38 MAPK (LY2228820) and Aurora A (MLN8237) increased aluminum-activated malate transport via AtALMT1, suggesting that both MLN8237 and LY2228820 interfere with AtALMT1 activity. An increase in root elongation was also observed in Arabidopsis after applying compounds LY2228820 and MLN8237. Thus, both LY2228820 and MLN8237 may play important roles in alleviating the inhibitory effects of aluminum on roots. |
| 巻・号 | 138(1) |
| ページ | 121-129 |
| 公開日 | 2025-1-1 |
| DOI | 10.1007/s10265-024-01594-5 |
| PII | 10.1007/s10265-024-01594-5 |
| PMID | 39505783 |
| MeSH | Aluminum* / pharmacology Aluminum* / toxicity Arabidopsis* / drug effects Arabidopsis* / genetics Arabidopsis Proteins* / genetics Arabidopsis Proteins* / metabolism Aurora Kinases / genetics Aurora Kinases / metabolism Gene Expression Regulation, Plant* / drug effects Malates* / metabolism Mitogen-Activated Protein Kinases / genetics Mitogen-Activated Protein Kinases / metabolism Organic Anion Transporters / genetics Organic Anion Transporters / metabolism Plant Roots / drug effects Plant Roots / genetics Transcription Factors p38 Mitogen-Activated Protein Kinases / genetics p38 Mitogen-Activated Protein Kinases / metabolism |
| IF | 2.185 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | sja05801 |