論文 - 詳細
| RRC ID | 82854 |
|---|---|
| 著者 | Félix R, Markov DA, Renninger SL, Tomás AR, Laborde A, Carey MR, Orger MB, Portugues R. |
| タイトル | Structural and Functional Organization of Visual Responses in the Inferior Olive of Larval Zebrafish. |
| ジャーナル | J Neurosci |
| Abstract |
The olivo-cerebellar system plays an important role in vertebrate sensorimotor control. Here, we investigate sensory representations in the inferior olive (IO) of larval zebrafish and their spatial organization. Using single-cell labeling of genetically identified IO neurons, we find that they can be divided into at least two distinct groups based on their spatial location, dendritic morphology, and axonal projection patterns. In the same genetically targeted population, we recorded calcium activity in response to a set of visual stimuli using two-photon imaging. We found that most IO neurons showed direction-selective and binocular responses to visual stimuli and that the functional properties were spatially organized within the IO. Light-sheet functional imaging that allowed for simultaneous activity recordings at the soma and axonal level revealed tight coupling between functional properties, soma location, and axonal projection patterns of IO neurons. Taken together, our results suggest that anatomically defined classes of IO neurons correspond to distinct functional types, and that topographic connections between IO and cerebellum contribute to organization of the cerebellum into distinct functional zones. |
| 巻・号 | 44(8) |
| 公開日 | 2024-2-21 |
| DOI | 10.1523/JNEUROSCI.2352-21.2023 |
| PII | JNEUROSCI.2352-21.2023 |
| PMID | 38195508 |
| PMC | PMC10883660 |
| MeSH | Animals Cerebellum / physiology Larva Neurons / physiology Olivary Nucleus* / physiology Zebrafish* |
| IF | 5.674 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | hspGFFDMC28C, UAS:GFP |