論文 - 詳細
| RRC ID | 83089 |
|---|---|
| 著者 | Kasai F, Fukushima M, Miyagi Y, Nakamura Y. |
| タイトル | Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan. |
| ジャーナル | Hum Cell |
| Abstract |
Japan is often assumed to have a highly homogeneous ethnic population, because it is an island country. This is evident in human cell lines collected from cell banks; however, these genotypes have not been thoroughly characterized. To examine the population genotypes of human cell lines established in Japan, we conducted SNP genotyping on 57 noncancerous cell lines and 43 lung cancer cell lines. Analysis of biogeographic ancestry revealed that 58 cell lines had non-admixed Japanese genotypes, 21 cell lines had an admixture of Japanese and East Asian genotypes, and the remaining 21 cell lines had East Asian genotypes. The proportion of non-admixed Japanese genotypes was similar between lung cancer and noncancerous cell lines, suggesting that patients in Japan may not exclusively have Japanese genotypes. This could influence the incidence of inherited diseases and should be taken into account in personalized medicine tailored to genetic background. The genetic makeup of the present-day Japanese population cannot be fully explained by the ancestral Jomon and Yayoi lineages. Instead, it is necessary to consider a certain level of genetic admixture between Japanese and neighboring Asian populations. Our study revealed genetic variation among human cell lines derived from Japanese individuals, reflecting the diversity present within the Japanese population. |
| 巻・号 | 37(4) |
| ページ | 944-950 |
| 公開日 | 2024-7-1 |
| DOI | 10.1007/s13577-024-01055-0 |
| PII | 10.1007/s13577-024-01055-0 |
| PMID | 38639832 |
| PMC | PMC11194210 |
| MeSH | Cell Line Cell Line, Tumor East Asian People* / genetics Genetic Variation* Genotype Humans Japan Lung Neoplasms / genetics Polymorphism, Single Nucleotide |
| IF | 3.463 |
| リソース情報 | |
| ヒト・動物細胞 | HEV0031 HEV0032 HEV0034 HEV0037 HEV0039 HEV0054 HEV0098 HEV0101 HEV0114 HEV0121 HEV0149 HEV0178 HEV0208 HEV0218 HEV0236 HEV0240 HEV0251 HEV0295 HEV0300 HEV0325 HEV0333 HEV0380 HEV0388 HEV0404 HEV0410 HEV0421 HEV0498 HEV0500 HLC-1(RCB0083) HUC-F(RCB0153) HS-K(RCB0159) NHSF46(RCB0162) HUC-Fm(RCB0197) NB1RGB(RCB0222) HUC-F2(RCB0436) HUC-Fm2(RCB0437) LC-2/ad(RCB0440) RERF-LC-AI(RCB0444) LC-1/sq(RCB0455) Lu-134-A(RCB0466) Lu-135(RCB0468) Lu-139(RCB0469) Lu-140(RCB0470) HFL-I(RCB0521) HFL-II(RCB0522) HFL-III(RCB0523) IA-LM(RCB0554) SF8406(RCB0584) HFL-AE-III(RCB0684) HFSKF-II(RCB0698) MS-1(RCB0725) T3M-10(RCB1020) T3M-11(RCB1022) HFSKF-AE-V(RCB1139) Lu-165(RCB1184) RERF-LC-KJ(RCB1313) LCAM1(RCB1425) HFSK9t(RCB1542) HFL-AE-VI(RCB1613) HFL-AE-VII(RCB1617) Lu-24(RCB1771) Lu-141(RCB1772) Lu-143(RCB1773) Lu-138(RCB1785) Lu99(RCB1900) Sq-1(RCB1905) EBC-1(RCB1965) S1(RCB1966) LU65(RCB1967) LK-2(RCB1970) UCB-TERT-21(RCB2079) 31898(RCB2092) II-18(RCB2093) S2(RCB2133) 31444(RCB2134) UE6E7-16(RCB2163) HE16(RCB2237) HE31(RCB2248) HE40(RCB2259) WA-hT(RCB2279) T3M-12(RCB2281) CB-3512(RCB2531) A110L(RCB2816) A529L(RCB2817) B1203L(RCB2818) C831L(RCB2819) G603L(RCB3529) B901L(RCB3530) A904L(RCB3531) A129L(RCB3532) PC-9(RCB4455) TIG-1(RCB4467) TIG-3(RCB4468) TIG-7(RCB4469) MCC138c(RCB5007) MCC148c(RCB5008) Y-ML-1B(RCB5394) |