| RRC ID |
83140
|
| Author |
Jamiolkowski RM, Nguyen QA, Farrell JS, McGinn RJ, Hartmann DA, Nirschl JJ, Sanchez MI, Buch VP, Soltesz I.
|
| Title |
The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy.
|
| Journal |
Nat Med
|
| Abstract |
Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy. However, a substantial proportion continues to suffer from seizures even after surgery. We identified the fasciola cinereum (FC) neurons of the posterior hippocampal tail as an important seizure node in both mice and humans with epilepsy. Genetically defined FC neurons were highly active during spontaneous seizures in epileptic mice, and closed-loop optogenetic inhibition of these neurons potently reduced seizure duration. Furthermore, we specifically targeted and found the prominent involvement of FC during seizures in a cohort of six patients with epilepsy. In particular, targeted lesioning of the FC in a patient reduced the seizure burden present after ablation of anterior mesial temporal structures. Thus, the FC may be a promising interventional target in epilepsy.
|
| Volume |
30(5)
|
| Pages |
1292-1299
|
| Published |
2024-5-1
|
| DOI |
10.1038/s41591-024-02924-9
|
| PII |
10.1038/s41591-024-02924-9
|
| PMID |
38632391
|
| PMC |
PMC11108783
|
| MeSH |
Adult
Animals
Epilepsy / pathology
Epilepsy, Temporal Lobe / pathology
Epilepsy, Temporal Lobe / physiopathology
Female
Hippocampus* / pathology
Humans
Male
Mice
Neurons* / pathology
Optogenetics
Seizures
|
| IF |
36.13
|
| Resource |
| Mice |
RBRC05662 |
