論文 - 詳細
| RRC ID | 83192 |
|---|---|
| 著者 | Hilzinger JM, Friedline S, Sivanandan D, Cheng YF, Yamazaki S, Clark DS, Skerker JM, Arkin AP. |
| タイトル | Acetaminophen production in the edible, filamentous cyanobacterium Arthrospira platensis. |
| ジャーナル | Biotechnol Bioeng |
| Abstract |
Spirulina is the common name for the edible, nonheterocystous, filamentous cyanobacterium Arthrospira platensis that is grown industrially as a food supplement, animal feedstock, and pigment source. Although there are many applications for engineering this organism, until recently no genetic tools or reproducible transformation methods have been published. While recent work showed the production of a diversity of proteins in A. platensis, including single-domain antibodies for oral delivery, there remains a need for a modular, characterized genetic toolkit. Here, we independently establish a reproducible method for the transformation of A. platensis and engineer this bacterium to produce acetaminophen as proof-of-concept for small molecule production in an edible host. This work opens A. platensis to the wider scientific community for future engineering as a functional food for nutritional enhancement, modification of organoleptic traits, and production of pharmaceuticals for oral delivery. |
| 巻・号 | 122(1) |
| ページ | 44-52 |
| 公開日 | 2025-1-1 |
| DOI | 10.1002/bit.28858 |
| PMID | 39392130 |
| PMC | PMC11632167 |
| MeSH | Acetaminophen* / metabolism Metabolic Engineering / methods Spirulina* / genetics Spirulina* / metabolism |
| IF | 4.002 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-39 |