論文 - 詳細
| RRC ID | 83225 |
|---|---|
| 著者 | Sakata A, Tatsumi K, Matsumoto N, Mackman N, Harada S, Kawasaki R, Okuyama-Nishida Y, Soeda T, Nogami K, Shima M. |
| タイトル | Extravascular coagulation regulates haemostasis independently of activated platelet surfaces in an in vivo mouse model. |
| ジャーナル | Commun Biol |
| Abstract |
While the conventional understanding of haemostatic plug formation is that coagulation proceeds efficiently on the surface of activated platelets at the vascular injury site to form a robust haemostatic plug, this understanding does not explain the clinical reality that platelet dysfunction results in a mild bleeding phenotype, whereas coagulation disorders exhibit severe bleeding phenotypes, particularly in deep tissues. Here, we introduce an in vivo imaging method to observe internal bleeding and subsequent haemostatic plug formation in mice and report that haemostatic plug formation after internal bleeding, coagulation occurs primarily outside the blood vessel rather than on platelets. Experiments in mice with impaired platelet surface coagulation, depleted platelets, haemophilia A or reduced tissue factor expression suggest that this extravascular coagulation triggers and regulates haemostatic plug formation. Our discovery of the important role of extravascular coagulation in haemostasis may contribute to refining the treatment of haemostatic abnormalities and advancing antithrombotic therapy. |
| 巻・号 | 8(1) |
| ページ | 390 |
| 公開日 | 2025-3-8 |
| DOI | 10.1038/s42003-025-07838-x |
| PII | 10.1038/s42003-025-07838-x |
| PMID | 40055470 |
| MeSH | Animals Blood Coagulation* Blood Platelets* / metabolism Blood Platelets* / physiology Disease Models, Animal* Hemorrhage / metabolism Hemostasis* Male Mice Mice, Inbred C57BL Platelet Activation |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC09796 |