| RRC ID |
83319
|
| 著者 |
Chen Z, Liu X, You J, Tomaskovic-Crook E, Yue Z, Talaei A, Sutton G, Crook J, Wallace G.
|
| タイトル |
Electro-compacted collagen for corneal epithelial tissue engineering.
|
| ジャーナル |
J Biomed Mater Res A
|
| Abstract |
Bioengineered corneal substitutes offer a solution to the shortage of donor corneal tissue worldwide. As one of the major structural components of the cornea, collagen has shown great potential for tissue-engineered cornea substitutes. Herein, free-standing collagen membranes fabricated using electro-compaction were assessed in corneal bioengineering application by comparing them with nonelectro-compacted collagen (NECC). The well-organized and biomimetic fibril structure resulted in a significant improvement in mechanical properties. A 10-fold increase in tensile and compressive modulus was recorded when compared with NECC membranes. In addition to comparable transparency in the visible light range, the glucose permeability of the electro-compacted collagen (ECC) membrane is higher than that of the native human cornea. Human corneal epithelial cells adhere and proliferate well on the ECC membrane, with a large cell contact area observed. The as-described ECC has appropriate structural, topographic, mechanical, optical, glucose permeable, and cell support properties to provide a platform for a bioengineered cornea; including the outer corneal epithelium and potentially deeper corneal tissues.
|
| 巻・号 |
111(8)
|
| ページ |
1151-1160
|
| 公開日 |
2023-8-1
|
| DOI |
10.1002/jbm.a.37500
|
| PMID |
36651651
|
| MeSH |
Collagen / chemistry
Cornea
Epithelium, Corneal*
Glucose
Humans
Tissue Engineering / methods
|
| IF |
3.525
|
| リソース情報 |
| ヒト・動物細胞 |
HCE-T(RCB2280) |
