論文 - 詳細
| RRC ID | 83319 |
|---|---|
| 著者 | Chen Z, Liu X, You J, Tomaskovic-Crook E, Yue Z, Talaei A, Sutton G, Crook J, Wallace G. |
| タイトル | Electro-compacted collagen for corneal epithelial tissue engineering. |
| ジャーナル | J Biomed Mater Res A |
| Abstract |
Bioengineered corneal substitutes offer a solution to the shortage of donor corneal tissue worldwide. As one of the major structural components of the cornea, collagen has shown great potential for tissue-engineered cornea substitutes. Herein, free-standing collagen membranes fabricated using electro-compaction were assessed in corneal bioengineering application by comparing them with nonelectro-compacted collagen (NECC). The well-organized and biomimetic fibril structure resulted in a significant improvement in mechanical properties. A 10-fold increase in tensile and compressive modulus was recorded when compared with NECC membranes. In addition to comparable transparency in the visible light range, the glucose permeability of the electro-compacted collagen (ECC) membrane is higher than that of the native human cornea. Human corneal epithelial cells adhere and proliferate well on the ECC membrane, with a large cell contact area observed. The as-described ECC has appropriate structural, topographic, mechanical, optical, glucose permeable, and cell support properties to provide a platform for a bioengineered cornea; including the outer corneal epithelium and potentially deeper corneal tissues. |
| 巻・号 | 111(8) |
| ページ | 1151-1160 |
| 公開日 | 2023-8-1 |
| DOI | 10.1002/jbm.a.37500 |
| PMID | 36651651 |
| MeSH | Collagen / chemistry Cornea Epithelium, Corneal* Glucose Humans Tissue Engineering / methods |
| IF | 3.525 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HCE-T(RCB2280) |