Reference - Detail
| RRC ID | 83382 |
|---|---|
| Author | Morikawa T, Inoue N, Yamamoto S, Shiotani M, Manse Y, Ninomiya K. |
| Title | Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino. |
| Journal | J Nat Med |
| Abstract |
Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome (Cnidii Rhizoma; "Senkyu" in Japanese) and is listed in the Japanese Pharmacopoeia XVIII, showed intracellular triglyceride metabolism-promoting activity in high glucose-pretreated HepG2 cells. Thirty-five constituents, including two new alkylphthalide glycosides, senkyunosides A (1) and B (2), and a neolignan with a new stereoisomeric structure (3), were isolated in the extract. Their stereostructures were elucidated based on chemical and spectroscopic evidence. Among the isolates, several alkylphthalides, (Z)-3-butylidene-7-methoxyphthalide (9) and senkyunolides G (10), H (14), and I (15), and a polyacetylene falcarindiol (26), were found to show significant activity without any cytotoxicity at 10 μM. |
| Volume | 78(3) |
| Pages | 709-721 |
| Published | 2024-6-1 |
| DOI | 10.1007/s11418-024-01799-x |
| PII | 10.1007/s11418-024-01799-x |
| PMID | 38575838 |
| MeSH | Benzofurans* / chemistry Benzofurans* / isolation & purification Benzofurans* / pharmacology Cnidium* / chemistry Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology Hep G2 Cells Humans Molecular Structure Plant Extracts / chemistry Plant Extracts / pharmacology Rhizome* / chemistry Triglycerides* / metabolism |
| IF | 2.055 |
| Resource | |
| Human and Animal Cells | Hep G2(RCB1648) |