| RRC ID |
83383
|
| 著者 |
Saeki T, Yamamoto S, Akaki J, Tanaka T, Nakasone M, Ikeda H, Wang W, Inoue M, Manse Y, Ninomiya K, Morikawa T.
|
| タイトル |
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity.
|
| ジャーナル |
J Nat Med
|
| Abstract |
This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obesity-reducing effects of a Kampo medicine, bofutsushosan (BTS; fangfengtongshengsan in Chinese). Aged mice fed a high-fat diet containing 2% BTS extract for 28 days exhibited a significant reduction in weight gain and accumulation of visceral and subcutaneous fat, which were greater degree of reduction than those of the young mice. When the treatment period was extended to two months, the serum aspartate aminotransferase and alanine aminotransferase levels and the accumulation of fat droplets in the hepatocytes decreased. The mRNA expression of mitochondrial uncoupling protein 1 (UCP1) in the brown adipose tissue was significantly reduced in the aged mice compared to the young mice but increased by 2% in the BTS-treated aged mice. Additionally, the effect of BTS extract on oleic acid-albumin-induced triglyceride accumulation in hepatoblastoma-derived HepG2 cells was significantly inhibited in a concentration-dependent manner. Evaluation of the single crude drug extracts revealed that Forsythia Fruit, Schizonepeta Spike, and Rhubarb were the active components in BTS extract. These results suggest that BTS extract is effective against visceral, subcutaneous, and ectopic fats in the liver, which tend to accumulate with aging. Thus, BTS extract is useful in preventing and ameliorating the development of obesity and metabolic syndrome.
|
| 巻・号 |
78(3)
|
| ページ |
576-589
|
| 公開日 |
2024-6-1
|
| DOI |
10.1007/s11418-024-01803-4
|
| PII |
10.1007/s11418-024-01803-4
|
| PMID |
38662301
|
| PMC |
PMC11937147
|
| MeSH |
Aging* / drug effects
Animals
Aspartate Aminotransferases / blood
Diet, High-Fat* / adverse effects
Drugs, Chinese Herbal* / chemistry
Drugs, Chinese Herbal* / pharmacology
Hep G2 Cells
Humans
Male
Mice
Mice, Inbred C57BL
Obesity* / drug therapy
Obesity* / metabolism
Plant Extracts / chemistry
Plant Extracts / pharmacology
Triglycerides / blood
Triglycerides / metabolism
Uncoupling Protein 1 / metabolism
|
| IF |
2.055
|
| リソース情報 |
| ヒト・動物細胞 |
Hep G2(RCB1648) |
