論文 - 詳細
| RRC ID | 83419 |
|---|---|
| 著者 | Kashio S, Obata F, Zhang L, Katsuyama T, Chihara T, Miura M. |
| タイトル | Tissue nonautonomous effects of fat body methionine metabolism on imaginal disc repair in Drosophila. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Regulatory mechanisms for tissue repair and regeneration within damaged tissue have been extensively studied. However, the systemic regulation of tissue repair remains poorly understood. To elucidate tissue nonautonomous control of repair process, it is essential to induce local damage, independent of genetic manipulations in uninjured parts of the body. Herein, we develop a system in Drosophila for spatiotemporal tissue injury using a temperature-sensitive form of diphtheria toxin A domain driven by the Q system to study factors contributing to imaginal disc repair. Using this technique, we demonstrate that methionine metabolism in the fat body, a counterpart of mammalian liver and adipose tissue, supports the repair processes of wing discs. Local injury to wing discs decreases methionine and S-adenosylmethionine, whereas it increases S-adenosylhomocysteine in the fat body. Fat body-specific genetic manipulation of methionine metabolism results in defective disc repair but does not affect normal wing development. Our data indicate the contribution of tissue interactions to tissue repair in Drosophila, as local damage to wing discs influences fat body metabolism, and proper control of methionine metabolism in the fat body, in turn, affects wing regeneration. |
| 巻・号 | 113(7) |
| ページ | 1835-40 |
| 公開日 | 2016-2-16 |
| DOI | 10.1073/pnas.1523681113 |
| PII | 1523681113 |
| PMID | 26831070 |
| PMC | PMC4763779 |
| MeSH | Animals Drosophila melanogaster / physiology* Fat Body / metabolism* Imaginal Discs / physiology* Methionine / metabolism* Regeneration Temperature Wings, Animal / metabolism |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119591 DGRC#119592 DGRC#119593 |