論文 - 詳細
| RRC ID | 83462 |
|---|---|
| 著者 | Brimson CA, Baines R, Sams-Dodd E, Stefanescu I, Evans B, Kuwana S, Hashimura H, Sawai S, Thompson CRL. |
| タイトル | Collective oscillatory signaling in Dictyostelium discoideum acts as a developmental timer initiated by weak coupling of a noisy pulsatile signal. |
| ジャーナル | Dev Cell |
| Abstract |
Oscillatory phenomena play widespread roles in the control of biological systems. In D. discoideum, oscillatory cyclic adenosine monophosphate (cAMP) signaling drives collective behavior and induces a temporal developmental gene expression program. How collective cAMP oscillations emerge or how they encode temporal transcriptional information is still poorly understood. To address this, we identified a transcription factor required for the initiation of collective behavior. Hbx5 activity is cAMP dependent and provides a sensitive single-cell readout for cAMP signaling. Extensive stochastic pulsatile cAMP signaling is found to precede collective oscillations. Stochastic signaling induces Hbx5-dependent transcriptional feedback, which enhances signal sensitivity and cell-cell coupling. This results in the emergence of synchronized collective oscillations, which subsequently activates the GtaC transcription factor and triggers shifts in developmental gene expression. Our results suggest this temporal coordination is encoded by changes in the amplitude of cAMP oscillations and differential sensitivity of these transcription factors to the cAMP-regulated kinase ErkB. |
| 巻・号 | 60(6) |
| ページ | 918-933.e4 |
| 公開日 | 2025-3-24 |
| DOI | 10.1016/j.devcel.2024.11.016 |
| PII | S1534-5807(24)00698-1 |
| PMID | 39672161 |
| MeSH | Cyclic AMP* / metabolism Dictyostelium* / genetics Dictyostelium* / growth & development Dictyostelium* / metabolism Gene Expression Regulation, Developmental Protozoan Proteins / genetics Protozoan Proteins / metabolism Signal Transduction* Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 10.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | Achilles/pRSETB (RDB15982) |