| RRC ID |
83499
|
| 著者 |
Carvalho EO, Fernandes MM, Ivanova K, Rodriguez-Lejarraga P, Tzanov T, Ribeiro C, Lanceros-Mendez S.
|
| タイトル |
Multifunctional piezoelectric surfaces enhanced with layer-by-layer coating for improved osseointegration and antibacterial performance.
|
| ジャーナル |
Colloids Surf B Biointerfaces
|
| Abstract |
Implant failure is primarily caused by poor osseointegration and bacterial colonization, which demands readmissions and revision surgeries to correct it. A novel approach involves engineering multifunctional interfaces using piezoelectric polyvinylidene fluoride (PVDF) materials, which mimic bone tissue's electroactive properties to promote bone integration and provide antibacterial functionality when mechanically stimulated. In this study, PVDF films were coated with antibacterial essential oil nanoparticles and antibiofilm enzymes using a layer-by-layer (LBL) approach to ensure antibacterial properties even without mechanical stimulation. The experimental results confirmed the LBL build-up and demonstrated notable antibiofilm properties against Pseudomonas aeruginosa and Staphylococcus aureus while enhancing pre-osteoblast cell proliferation under mechanical dynamic conditions in a bioreactor that replicated the real-life environment of implants within the body. The findings highlight the potential of PVDF-coated surfaces to prevent biofilm formation and boost cell proliferation through the piezoelectric effect, paving the way for advanced implantable devices with improved osseointegration and antibacterial performance.
|
| 巻・号 |
243
|
| ページ |
114123
|
| 公開日 |
2024-11-1
|
| DOI |
10.1016/j.colsurfb.2024.114123
|
| PII |
S0927-7765(24)00382-5
|
| PMID |
39079183
|
| MeSH |
Animals
Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Biofilms* / drug effects
Cell Proliferation* / drug effects
Coated Materials, Biocompatible* / chemistry
Coated Materials, Biocompatible* / pharmacology
Fluorocarbon Polymers
Mice
Microbial Sensitivity Tests
Osseointegration* / drug effects
Osteoblasts / cytology
Osteoblasts / drug effects
Polyvinyls* / chemistry
Polyvinyls* / pharmacology
Pseudomonas aeruginosa* / drug effects
Pseudomonas aeruginosa* / physiology
Staphylococcus aureus* / drug effects
Staphylococcus aureus* / physiology
Surface Properties*
|
| IF |
4.389
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
