| RRC ID |
83503
|
| Author |
Tanaka T, Sano K, Kawakami R, Tanaka S, Munekane M, Yamasaki T, Mukai T.
|
| Title |
Electrostatically self-assembled gold nanorods with sulfated hyaluronic acid for targeted photothermal therapy for CD44-positive tumors.
|
| Journal |
Nanomedicine
|
| Abstract |
Gold nanorods (GNR) produce heat upon irradiation with near-infrared light, enabling a tumor-targeted photothermal therapy. In this study, we prepared GNR coated with sulfated hyaluronic acid (sHA) with a binding affinity for CD44 via electrostatic interactions to deliver GNR to tumors efficiently and stably, and evaluated their usefulness for photothermal therapy. Cationic GNR modified with trimethylammonium groups electrostatically interacted with native HA or sHA with varying degrees of sulfation to form complexes. While GNR/HA was unstable in saline, GNR/sHA maintained the absorbance peak in the near-infrared region, particularly for GNR/sHA with higher degrees of sulfation. GNR/sHA exhibited an intense photothermal effect upon irradiation with near-infrared light. Furthermore, in vitro and in vivo studies revealed that GNR coated with sHA containing approximately 1.2 sulfated groups per HA unit could accumulate in CD44-positive tumors via an HA-specific pathway. These findings indicate the effectiveness of GNR/sHA as a tumor-targeted photothermal therapeutic agent.
|
| Volume |
62
|
| Pages |
102781
|
| Published |
2024-11-1
|
| DOI |
10.1016/j.nano.2024.102781
|
| PII |
S1549-9634(24)00050-9
|
| PMID |
39163902
|
| MeSH |
Animals
Cell Line, Tumor
Female
Gold* / chemistry
Gold* / pharmacology
Humans
Hyaluronan Receptors* / metabolism
Hyaluronic Acid* / chemistry
Hyaluronic Acid* / pharmacology
Mice
Mice, Inbred BALB C
Mice, Nude
Nanotubes* / chemistry
Neoplasms / drug therapy
Neoplasms / therapy
Photothermal Therapy*
Static Electricity
Sulfates / chemistry
|
| IF |
4.3
|
| Resource |
| Human and Animal Cells |
MCF7(RCB1904)
T24 |
