Reference - Detail
| RRC ID | 83552 |
|---|---|
| Author | Ishida F, Onishi R, Takahashi D, Toshima K. |
| Title | A novel photosensitizer based on hypocrellin B activated by cysteine over-expressed in cancer cells. |
| Journal | Org Biomol Chem |
| Abstract |
L-Cysteine (Cys)-activatable photosensitizer 3 was designed and synthesized based on hypocrellin B (1). Cys is a novel tumor-associated biomarker. 3 exhibited negligible photosensitizing ability without Cys. However, when 1 was released from 3 by reaction with Cys, the photosensitizing activity was restored. Furthermore, 3 showed selective and effective photo-cytotoxicity against only cancer cells such as HeLa and A549 cells that highly express Cys when irradiated with 660 nm light, which is inside the phototherapeutic window. |
| Volume | 22(35) |
| Pages | 7187-7193 |
| Published | 2024-9-11 |
| DOI | 10.1039/d4ob01288g |
| PMID | 39158153 |
| MeSH | A549 Cells Antineoplastic Agents* / chemical synthesis Antineoplastic Agents* / chemistry Antineoplastic Agents* / pharmacology Cell Survival / drug effects Cysteine* / chemistry Drug Screening Assays, Antitumor HeLa Cells Humans Molecular Structure Perylene* / analogs & derivatives Perylene* / chemical synthesis Perylene* / chemistry Perylene* / pharmacology Photochemotherapy Photosensitizing Agents* / chemical synthesis Photosensitizing Agents* / chemistry Photosensitizing Agents* / pharmacology Quinones* / chemical synthesis Quinones* / chemistry Quinones* / pharmacology |
| IF | 3.412 |
| Resource | |
| Human and Animal Cells | MCF7(RCB1904) HeLa(RCB0007) A549(RCB0098) |