| RRC ID |
83571
|
| Author |
Hirasawa Y, Kase A, Okamoto A, Suzuki K, Hiroki M, Kaneda T, Uchiyama N, Morita H.
|
| Title |
Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus.
|
| Journal |
J Nat Med
|
| Abstract |
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of spectroscopic data as well as DP4 statistical analysis. Vincazalidine A induced G2 arrest and subsequent apoptosis in human lung carcinoma cell line, A549 cells.
|
| Volume |
78(2)
|
| Pages |
382-392
|
| Published |
2024-3-1
|
| DOI |
10.1007/s11418-023-01775-x
|
| PII |
10.1007/s11418-023-01775-x
|
| PMID |
38347371
|
| MeSH |
Alkaloids*
Antineoplastic Agents*
Aspidosperma* / chemistry
Aspidosperma* / metabolism
Catharanthus* / chemistry
Catharanthus* / metabolism
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / pharmacology
|
| IF |
2.055
|
| Resource |
| Human and Animal Cells |
A549 |
