論文 - 詳細
| RRC ID | 83578 |
|---|---|
| 著者 | Miki R, Yamaki T, Uchida M, Natsume H. |
| タイトル | Phenylboronate-salicylate ester cross-linked self-healing hydrogel composed of modified hyaluronan at physiological pH. |
| ジャーナル | Soft Matter |
| Abstract |
Several hydrogels with boronate/diol ester cross-linking have been reported. However, multiple synthetic steps or expensive reagents are required to modify some diol moieties into polymers. Therefore, diol-modified polymers, which are easily and inexpensively prepared via a single-step process, are required for the formation of boronate esters. This study reports a novel hydrogel composed of phenylboronic acid-modified hyaluronic acid and salicylic acid-modified hyaluronic acid. This hydrogel is injectable, can self-heal at physiological pH, and can be easily and inexpensively prepared. The polymer system behaved as a sol at pH 12.0 and a weak gel at pH 9.4 and 11.2, whereas it behaved as a gel over a wide pH range of 4.0-8.2. The viscoelasticity of the system decreased in response to sugar at pH 7.3. Thus, salicylic acid can be considered a promising diol moiety for hydrogel formation via boronate ester cross-linking. |
| 巻・号 | 20(13) |
| ページ | 2926-2936 |
| 公開日 | 2024-3-27 |
| DOI | 10.1039/d3sm01417g |
| PMID | 38466036 |
| MeSH | Boronic Acids* Esters Hyaluronic Acid* Hydrogels* Hydrogen-Ion Concentration Polymers Salicylic Acid |
| IF | 3.14 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549 |