| RRC ID |
83593
|
| 著者 |
Esparza J, Quintanilla JP, Cid E, Medeiros AC, Gallego JA, de la Prida LM.
|
| タイトル |
Cell-type-specific manifold analysis discloses independent geometric transformations in the hippocampal spatial code.
|
| ジャーナル |
Neuron
|
| Abstract |
Integrating analyses of genetically defined cell types with population-level approaches remains poorly explored. We investigated this question by focusing on hippocampal spatial maps and the contribution of two genetically defined pyramidal cell types in the deep and superficial CA1 sublayers. Using single- and dual-color miniscope imaging in mice running along a linear track, we found that population activity from these cells exhibited three-dimensional ring manifolds that encoded the animal position and running direction. Despite shared topology, sublayer-specific manifolds displayed distinct geometric features. Manipulating track orientation revealed rotational and translational changes in manifolds from deep cells, contrasting with more stable representations by superficial cells. These transformations were not observed in manifolds derived from the entire CA1 population. Instead, cell-type-specific chemogenetic silencing of either sublayer revealed independent geometric codes. Our results show how genetically specified subpopulations may underpin parallel spatial maps that can be manipulated independently.
|
| 巻・号 |
113(7)
|
| ページ |
1098-1109.e6
|
| 公開日 |
2025-4-2
|
| DOI |
10.1016/j.neuron.2025.01.022
|
| PII |
S0896-6273(25)00048-0
|
| PMID |
40015277
|
| MeSH |
Animals
CA1 Region, Hippocampal* / cytology
CA1 Region, Hippocampal* / physiology
Hippocampus* / cytology
Hippocampus* / physiology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Pyramidal Cells* / cytology
Pyramidal Cells* / physiology
Running / physiology
|
| IF |
14.415
|
| リソース情報 |
| 実験動物マウス |
RBRC06579 |
