| RRC ID |
83605
|
| Author |
Zhang Y, Bejaoui M, Linh TN, Arimura T, Isoda H.
|
| Title |
A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo.
|
| Journal |
Cell Commun Signal
|
| Abstract |
Squalene (SQ) is a well-known antioxidant and anti-inflammatory agent that provides promising anti-aging and UV-protective roles on human skin. However, its strong hydrophobic nature, accompanied by issues such as poor solubility and limited tissue permeation, has created challenges for scientists to investigate its untapped potential in more complex conditions, including cancer progression. The present study assessed the potent anti-metastatic properties of a newly synthesized amphiphilic ethylene glycol SQ derivative (SQ-diEG) in melanoma, the most fatal skin cancer. In vitro and in vivo experiments have discovered that SQ-diEG may exert its potential on melanoma malignancy through the mitochondria-mediated caspase activation apoptotic signaling pathway. The potent anti-metastatic effect of SQ-diEG was observed in vitro using highly proliferative and aggressive melanoma cells. Administration of SQ-diEG (25 mg/kg) significantly decreased the tumor burden on the lung and inhibited the metastasis-associated proteins and gene markers in B16F10 lung colonization mice model. Furthermore, global gene profiling also revealed a promising role of SQ-diEG in tumor microenvironment. We anticipated that the amphiphilic nature of the SQ compound bearing ethylene glycol oligomers could potentially augment its ability to reach the pathology site, thus enhancing its therapeutic potential in melanoma.
|
| Volume |
22(1)
|
| Pages |
437
|
| Published |
2024-9-11
|
| DOI |
10.1186/s12964-024-01813-5
|
| PII |
10.1186/s12964-024-01813-5
|
| PMID |
39261954
|
| PMC |
PMC11389383
|
| MeSH |
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use
Apoptosis / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Ethers / chemistry
Ethers / pharmacology
Humans
Lung Neoplasms / drug therapy
Lung Neoplasms / pathology
Lung Neoplasms / secondary
Melanoma* / drug therapy
Melanoma* / pathology
Melanoma, Experimental / drug therapy
Melanoma, Experimental / pathology
Mice
Mice, Inbred C57BL
Neoplasm Metastasis
Skin Neoplasms / drug therapy
Skin Neoplasms / pathology
Squalene* / chemistry
Squalene* / pharmacology
Tumor Microenvironment / drug effects
|
| IF |
4.344
|
| Resource |
| Human and Animal Cells |
B16F10(RCB2630) |
