論文 - 詳細
| RRC ID | 83666 |
|---|---|
| 著者 | Sakamoto Y, Furuhashi A, Mufundirwa A, Sugiyama T, Atsuta I, Ayukawa Y. |
| タイトル | Enhancing epithelial tissue sealing of titanium alloy implants through CaCl2-based hydrothermal treatment. |
| ジャーナル | Biointerphases |
| Abstract |
The long-term stability of dental implants is significantly influenced by their resistance to foreign factors in the peri-implant epithelium (PIE). Despite this, enhancing the sealing properties at the implant-PIE interface continues to be an unmet clinical need. Ti-6Al-4V (Ti64) alloy has higher tensile strength and hardness than pure titanium. This study was to verify whether hydrothermal treatment of Ti64 alloy implants with distilled water (HT-DW) or calcium chloride (CaCl2) solution (HT-Ca) could improve the sealing of the PIE around Ti64 implants. The existence of calcium (Ca) on the surface of HT-Ca implants was confirmed using x-ray photoelectron spectroscopy and synchrotron-based x-ray absorption fine structure techniques. These data showed that the surface was oxidized, and Ca existed in the form of anhydrous CaCl2 and calcium titanate. Laminin-332 (Ln), which is an essential component of epithelial adhesion structures, was observed between all types of implants and the PIE, 4 weeks after implantation in rat maxillae. Ln distribution over the entire epithelial interface was similar for the HT-Ca implant and a natural tooth. Moreover, the HT-Ca implant inhibited foreign body penetration, which indicated stronger gingival sealing at the implant-PIE interface, compared with the untreated and HT-DW implants. We also investigated the attachment of mouse-derived gingival epithelial cells (GE1). GE1 adherence was stronger and Ln expression levels were higher for HT-Ca plates compared with the untreated and HT-DW plates. Our results demonstrate that hydrothermal treatment of Ti64 implants with CaCl2 solution facilitates the growth of an effective soft tissue seal around the implant. |
| 巻・号 | 20(2) |
| 公開日 | 2025-3-1 |
| DOI | 10.1116/6.0004359 |
| PII | 3343713 |
| PMID | 40214256 |
| MeSH | Alloys / chemistry Animals Calcium Chloride* / chemistry Dental Implants* Epithelium / drug effects Male Mice Photoelectron Spectroscopy Rats Rats, Sprague-Dawley Surface Properties Titanium* / chemistry Water / chemistry |
| IF | 2.043 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | GE1(RCB1709) |