論文 - 詳細
| RRC ID | 83669 |
|---|---|
| 著者 | Saimoto Y, Kusakabe D, Morimoto K, Matsuoka Y, Kozakura E, Kato N, Tsunematsu K, Umeno T, Kiyotani T, Matsumoto S, Tsuji M, Hirayama T, Nagasawa H, Uchida K, Karasawa S, Jutanom M, Yamada KI. |
| タイトル | Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization. |
| ジャーナル | Nat Commun |
| Abstract |
Ferroptosis, a form of cell death instigated by iron-dependent lipid peroxidation reactions (LPO), is emerging as a promising therapeutic target for cancer. While the mechanisms governing LPO induction and suppression have gradually been unveiled, questions persist regarding the specific cellular location of LPO and the utilization of iron in driving cell death. A comprehensive understanding of these aspects holds significant potential for advancing therapeutic applications in disease management. Here, we show lysosomal LPO in the initiation of ferroptosis, leveraging the hidden abilities of fluorescent detection probes. Intra-lysosomal LPO triggers iron leakage, fostering cell-wide LPO by augmenting lysosomal membrane permeabilization (LMP). Conversely, cell lines with low susceptibility to ferroptosis do not exhibit LMP. This deficiency is rectified by the concurrent administration of chloroquine, leading to LMP induction and subsequent cell death. These findings underscore enhancing LMP induction efficacy as a strategic approach to surmount resistance to therapies in cancer. |
| 巻・号 | 16(1) |
| ページ | 3554 |
| 公開日 | 2025-4-15 |
| DOI | 10.1038/s41467-025-58909-w |
| PII | 10.1038/s41467-025-58909-w |
| PMID | 40229298 |
| PMC | PMC11997074 |
| MeSH | Animals Cell Death / drug effects Cell Line, Tumor Chloroquine / pharmacology Ferroptosis* / drug effects Ferroptosis* / physiology Humans Intracellular Membranes* / drug effects Intracellular Membranes* / metabolism Iron / metabolism Lipid Peroxidation* / drug effects Lysosomes* / drug effects Lysosomes* / metabolism Permeability / drug effects |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 41 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| ヒト・動物細胞 | IA-LM(RCB0554) |