| RRC ID |
83672
|
| 著者 |
Sano K, Mizukami T, Tanaka T, Nagayama T, Nakata M, Yamasaki M, Fukada T, Haratake Y, Munekane M, Yamasaki T, Mukai T.
|
| タイトル |
Intravenous administration of 90Y-labeled polyoxazoline combined with tumor heating potently inhibits tumor growth in mice.
|
| ジャーナル |
Int J Pharm
|
| Abstract |
The basic requirements for the development of radiopharmaceuticals for radionuclide therapy of tumors include marked tumor-specific accumulation and long-term intratumoral retention. We have previously reported an indium-111 (111In)-labeled thermoresponsive polymer (polyoxazoline (POZ)) that is soluble at body temperature with rapid clearance from normal tissues but self-aggregates in the tumor upon tumor heating treatment. POZ accumulated in the tumor via self-aggregation under hyperthermic conditions and was retained after stopping heat exposure. In this study, we investigated the cellular uptake of 111In-labeled POZ and the antitumor effects of radionuclide therapy using yttrium-90 (90Y)-labeled POZ in combination with tumor heating. A POZ derivative with a lower critical solution temperature (LCST) of 38 °C was efficiently taken up by Colon-26 tumor cells at temperatures above the LCST via phagocytosis. In the therapeutic study using 90Y-labeled POZ, a marked dose-dependent therapeutic effect of radioactivity was observed in the groups treated with 90Y-POZ combined with tumor heating with no obvious systemic side effects. These results demonstrated that thermoresponsive 90Y-labeled POZ showed a potent therapeutic effect in combination with tumor heating, suggesting the usefulness for radionuclide therapy of tumors.
|
| 巻・号 |
669
|
| ページ |
125103
|
| 公開日 |
2025-1-25
|
| DOI |
10.1016/j.ijpharm.2024.125103
|
| PII |
S0378-5173(24)01337-1
|
| PMID |
39708850
|
| MeSH |
Administration, Intravenous
Animals
Cell Line, Tumor
Colonic Neoplasms / pathology
Colonic Neoplasms / therapy
Combined Modality Therapy
Female
Hot Temperature
Hyperthermia, Induced / methods
Indium Radioisotopes / administration & dosage
Male
Mice
Mice, Inbred BALB C*
Oxazoles* / administration & dosage
Oxazoles* / chemistry
Radiopharmaceuticals / administration & dosage
Radiopharmaceuticals / chemistry
Radiopharmaceuticals / pharmacokinetics
Yttrium Radioisotopes* / administration & dosage
Yttrium Radioisotopes* / chemistry
|
| IF |
4.845
|
| リソース情報 |
| ヒト・動物細胞 |
Colon-26(RCB2657) |
