| RRC ID |
83677
|
| Author |
Ayaka Fukuda, Keita Sato, Chika Fujimori, Takahiro Yamashita, Atsuko Takeuchi, Hideyo Ohuchi, Chie Umatani, Shinji Kanda
|
| Title |
Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation
|
| Journal |
Science
|
| Abstract |
The recent discovery of nonvisual photoreceptors in various organs has raised expectations for uncovering their roles and underlying mechanisms. In this work, we identified a previously unrecognized hormone-releasing mechanism in the pituitary of the Japanese rice fish (medaka) induced by light. Ca
2+
imaging analysis revealed that melanotrophs, a type of pituitary endocrine cell that secretes melanocyte-stimulating hormone, robustly increase the concentration of intracellular Ca
2+
during short-wavelength light exposure. Moreover, we identified Opn5m as the key molecule that drives this response. Knocking out
opn5m
attenuated melanogenesis by reducing
tyrosinase
expression in the skin. Our findings suggest a mechanism in which direct reception of short-wavelength light by pituitary melanotrophs triggers a pathway that might contribute to protection from ultraviolet radiation in medaka.
|
| Volume |
387
|
| Pages |
43-48
|
| Published |
2025-1-3
|
| DOI |
10.1126/science.adj9687
|
| PMID |
39745961
|
| MeSH |
Animals
Calcium* / metabolism
Fish Proteins* / genetics
Fish Proteins* / metabolism
Melanins* / biosynthesis
Melanins* / genetics
Melanotrophs / metabolism
Monophenol Monooxygenase / metabolism
Opsins* / genetics
Opsins* / metabolism
Oryzias* / genetics
Oryzias* / metabolism
Pituitary Gland* / metabolism
Skin Pigmentation* / genetics
Ultraviolet Rays
|
| IF |
41.846
|
| Resource |
| Medaka |
d-rR/TOKYO (MT837)
Kiyosu (WS1177) |
