論文 - 詳細
| RRC ID | 83677 |
|---|---|
| 著者 | Ayaka Fukuda, Keita Sato, Chika Fujimori, Takahiro Yamashita, Atsuko Takeuchi, Hideyo Ohuchi, Chie Umatani, Shinji Kanda |
| タイトル | Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation |
| ジャーナル | Science |
| Abstract |
The recent discovery of nonvisual photoreceptors in various organs has raised expectations for uncovering their roles and underlying mechanisms. In this work, we identified a previously unrecognized hormone-releasing mechanism in the pituitary of the Japanese rice fish (medaka) induced by light. Ca
2+
imaging analysis revealed that melanotrophs, a type of pituitary endocrine cell that secretes melanocyte-stimulating hormone, robustly increase the concentration of intracellular Ca
2+
during short-wavelength light exposure. Moreover, we identified Opn5m as the key molecule that drives this response. Knocking out
opn5m
attenuated melanogenesis by reducing
tyrosinase
expression in the skin. Our findings suggest a mechanism in which direct reception of short-wavelength light by pituitary melanotrophs triggers a pathway that might contribute to protection from ultraviolet radiation in medaka. |
| 巻・号 | 387 |
| ページ | 43-48 |
| 公開日 | 2025-1-3 |
| DOI | 10.1126/science.adj9687 |
| PMID | 39745961 |
| MeSH | Animals Calcium* / metabolism Fish Proteins* / genetics Fish Proteins* / metabolism Melanins* / biosynthesis Melanins* / genetics Melanotrophs / metabolism Monophenol Monooxygenase / metabolism Opsins* / genetics Opsins* / metabolism Oryzias* / genetics Oryzias* / metabolism Pituitary Gland* / metabolism Skin Pigmentation* / genetics Ultraviolet Rays |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 179 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.8 |
| リソース情報 | |
| メダカ | d-rR/TOKYO (MT837) Kiyosu (WS1177) |