Reference - Detail
| RRC ID | 83683 |
|---|---|
| Author | Wang X, Kopinke D, Lin J, McPherson AD, Duncan RN, Otsuna H, Moro E, Hoshijima K, Grunwald DJ, Argenton F, Chien CB, Murtaugh LC, Dorsky RI. |
| Title | Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. |
| Journal | Dev Cell |
| Abstract |
Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation of unspecified hypothalamic progenitors in the embryo. At later stages, including adulthood, sequential activation and inhibition of Wnt activity is required for the differentiation of neural progenitors and negatively regulates radial glia differentiation. The presence of Wnt activity is conserved in hypothalamic progenitors of the adult mouse, where it plays a conserved role in inhibiting the differentiation of radial glia. This study establishes the vertebrate hypothalamus as a model for Wnt-regulated postembryonic neural progenitor differentiation and defines specific roles for Wnt signaling in neurogenesis. |
| Volume | 23(3) |
| Pages | 624-36 |
| Published | 2012-9-11 |
| DOI | 10.1016/j.devcel.2012.07.012 |
| PII | S1534-5807(12)00331-0 |
| PMID | 22975330 |
| PMC | PMC3445042 |
| MeSH | Animals Hypothalamus / cytology* Hypothalamus / metabolism Mice Neurogenesis* Neuroglia / cytology Neuroglia / metabolism Stem Cells / cytology* Stem Cells / metabolism Wnt Proteins / metabolism* Wnt Signaling Pathway* Zebrafish / embryology Zebrafish / growth & development* |
| IF | 10.092 |
| Resource | |
| Zebrafish | HG21C |