Reference - Detail
| RRC ID | 83721 |
|---|---|
| Author | Minowa T, Murata K, Mizue Y, Murai A, Nakatsugawa M, Sasaki K, Tokita S, Kubo T, Kanaseki T, Tsukahara T, Handa T, Sato S, Horimoto K, Kato J, Hida T, Hirohashi Y, Uhara H, Torigoe T. |
| Title | Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment. |
| Journal | Sci Transl Med |
| Abstract |
Acral lentiginous melanoma (ALM) is the most common melanoma subtype in non-Caucasians. Despite advances in cancer immunotherapy, current immune checkpoint inhibitors remain unsatisfactory for ALM. Hence, we conducted comprehensive immune profiling using single-cell phenotyping with reactivity screening of the T cell receptors of tumor-infiltrating T lymphocytes (TILs) in ALM. Compared with cutaneous melanoma, ALM showed a lower frequency of tumor-reactive CD8 clusters and an enrichment of regulatory T cells with direct tumor recognition ability, suggesting a suppressive immune microenvironment in ALM. Tumor-reactive CD8 TILs showed heterogeneous expression of coinhibitory molecules, including KLRC1 (NKG2A), in subpopulations with therapeutic implications. Overall, our study provides a foundation for enhancing the efficacy of immunotherapy in ALM. |
| Volume | 16(776) |
| Pages | eadk8832 |
| Published | 2024-12-4 |
| DOI | 10.1126/scitranslmed.adk8832 |
| PMID | 39630887 |
| MeSH | CD8-Positive T-Lymphocytes / immunology Female Humans Lymphocytes, Tumor-Infiltrating* / immunology Lymphocytes, Tumor-Infiltrating* / metabolism Male Melanoma* / immunology Melanoma* / pathology Middle Aged Single-Cell Analysis* Skin Neoplasms / immunology Skin Neoplasms / pathology Tumor Microenvironment* / immunology |
| IF | 16.304 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | HLA genes |