論文 - 詳細
| RRC ID | 83730 |
|---|---|
| 著者 | Kwok SH, Liu Y, Bilder D, Kim J. |
| タイトル | Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Tumors can induce systemic disturbances in distant organs, leading to physiological changes that enhance host morbidity. In Drosophila cancer models, tumors have been known for decades to cause hypervolemic "bloating" of the abdominal cavity. Here we use allograft and transgenic tumors to show that hosts display fluid retention associated with autonomously defective secretory capacity of fly renal tubules, which function analogous to those of the human kidney. Excretion from these organs is blocked by abnormal cells that originate from inappropriate activation of normally quiescent renal stem cells (RSCs). Blockage is initiated by IL-6-like oncokines that perturb renal water-transporting cells and trigger a damage response in RSCs that proceeds pathologically. Thus, a chronic inflammatory state produced by the tumor causes paraneoplastic fluid dysregulation by altering cellular homeostasis of host renal units. |
| 巻・号 | 121(42) |
| ページ | e2405860121 |
| 公開日 | 2024-10-15 |
| DOI | 10.1073/pnas.2405860121 |
| PMID | 39392665 |
| PMC | PMC11494367 |
| MeSH | Animals Animals, Genetically Modified Disease Models, Animal* Drosophila Drosophila melanogaster Humans Inflammation / pathology Interleukin-6 / metabolism Kidney / metabolism Kidney / pathology Kidney Diseases / etiology Kidney Diseases / immunology Kidney Diseases / pathology Kidney Tubules / metabolism Kidney Tubules / pathology Paraneoplastic Syndromes / immunology Paraneoplastic Syndromes / metabolism Paraneoplastic Syndromes / pathology Stem Cells* / metabolism |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104055 |