論文 - 詳細
| RRC ID | 83734 |
|---|---|
| 著者 | Ramesh P, Tiwari SK, Kaizer M, Jangra D, Ghosh K, Mandal S, Mandal L. |
| タイトル | The NF-κB Factor Relish maintains blood progenitor homeostasis in the developing Drosophila lymph gland. |
| ジャーナル | PLoS Genet |
| Abstract |
Post-larval hematopoiesis in Drosophila largely depends upon the stockpile of progenitors present in the blood-forming organ/lymph gland of the larvae. During larval stages, the lymph gland progenitors gradually accumulate reactive oxygen species (ROS), which is essential to prime them for differentiation. Studies have shown that ROS triggers the activation of JNK (c-Jun Kinase), which upregulates fatty acid oxidation (FAO) to facilitate progenitor differentiation. Intriguingly, despite having ROS, the entire progenitor pool does not differentiate simultaneously in the late larval stages. Using expression analyses, genetic manipulation and pharmacological approaches, we found that the Drosophila NF-κB transcription factor Relish (Rel) shields the progenitor pool from the metabolic pathway that inducts them into the differentiation program by curtailing the activation of JNK. Although ROS serves as the metabolic signal for progenitor differentiation, the input from ROS is monitored by the developmental signal TAK1, which is regulated by Relish. This developmental circuit ensures that the stockpile of ROS-primed progenitors is not exhausted entirely. Our study sheds light on how, during development, integrating NF-κB-like factors with metabolic pathways seem crucial to regulating cell fate transition during development. |
| 巻・号 | 20(9) |
| ページ | e1011403 |
| 公開日 | 2024-9-1 |
| DOI | 10.1371/journal.pgen.1011403 |
| PII | PGENETICS-D-24-00160 |
| PMID | 39250509 |
| PMC | PMC11424005 |
| MeSH | Animals Cell Differentiation* / genetics Drosophila / genetics Drosophila / growth & development Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental Hematopoiesis* / genetics Homeostasis* Larva* / genetics Larva* / growth & development Larva* / metabolism Lymphoid Tissue / growth & development Lymphoid Tissue / metabolism MAP Kinase Kinase Kinases / genetics MAP Kinase Kinase Kinases / metabolism NF-kappa B* / genetics NF-kappa B* / metabolism Reactive Oxygen Species* / metabolism Signal Transduction Stem Cells / cytology Stem Cells / metabolism Transcription Factors* / genetics Transcription Factors* / metabolism |
| IF | 5.175 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 38 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
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