| RRC ID |
83746
|
| Author |
Kaneko T, Boulanger-Weill J, Isabella AJ, Moens CB.
|
| Title |
Position-independent functional refinement within the vagus motor topographic map.
|
| Journal |
Cell Rep
|
| Abstract |
Motor neurons in the central nervous system often lie in a continuous topographic map, where neurons that innervate different body parts are spatially intermingled. This is the case for the efferent neurons of the vagus nerve, which innervate diverse muscle and organ targets in the head and viscera for brain-body communication. It remains elusive how neighboring motor neurons with different fixed peripheral axon targets develop the separate somatodendritic (input) connectivity they need to generate spatially precise body control. Here, we show that vagus motor neurons in the zebrafish indeed generate spatially appropriate peripheral responses to focal sensory stimulation even when they are transplanted into ectopic positions within the topographic map, indicating that circuit refinement occurs after the establishment of coarse topography. Refinement depends on motor neuron synaptic transmission, suggesting that an experience-dependent periphery-to-brain feedback mechanism establishes specific input connectivity among intermingled motor populations.
|
| Volume |
43(10)
|
| Pages |
114740
|
| Published |
2024-10-22
|
| DOI |
10.1016/j.celrep.2024.114740
|
| PII |
S2211-1247(24)01091-X
|
| PMID |
39325616
|
| PMC |
PMC11676005
|
| MeSH |
Animals
Axons / physiology
Motor Neurons* / physiology
Synaptic Transmission / physiology
Vagus Nerve* / physiology
Zebrafish* / physiology
|
| IF |
8.109
|
| Resource |
| Zebrafish |
UAS:GCaMP6s
UAS:BoTxBLCGFP |
