論文 - 詳細
| RRC ID | 83802 |
|---|---|
| 著者 | Gujar MR, Tan YS, Gao Y, Wang H. |
| タイトル | Arf1 and ARFGEF2/Sec71 control neuroblast polarity by anchoring nonmuscle myosin II. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Neural stem cells (NSCs) can self-renew and undergo differentiation via asymmetric division. Dysregulation in the balance between self-renewal and differentiation can lead to tumor formation or neurodevelopmental disorders. However, the regulation of phosphatidylinositol transfer protein (PITP)-dependent PI(4)P pools and myosin localization during asymmetric division in dividing cells is not well established. Here, we show that the Golgi proteins Arf1 and ARFGEF2/Sec71 control asymmetric division of Drosophila NSCs by facilitating the localization of myosin II regulatory light chain, Sqh, to the NSC cortex. Arf1 can physically associate with Sqh and Vibrator, a type I PITP that stimulates phospholipid PI4K activity for PI(4)P production. Further, Arf1 and Sec71 facilitate PI(4)P localization to the cell cortex of neuroblasts. Our data provide evidence that the Golgi proteins Arf1 and its GEF Sec71 facilitate neuroblast polarity through phospholipid-dependent nonmuscle myosin II cortical localization. |
| 巻・号 | 122(15) |
| ページ | e2419468122 |
| 公開日 | 2025-4-15 |
| DOI | 10.1073/pnas.2419468122 |
| PMID | 40208939 |
| PMC | PMC12012615 |
| MeSH | ADP-Ribosylation Factor 1* / genetics ADP-Ribosylation Factor 1* / metabolism Animals Cell Polarity* / physiology Drosophila Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / cytology Drosophila melanogaster / metabolism Golgi Apparatus / metabolism Guanine Nucleotide Exchange Factors* / genetics Guanine Nucleotide Exchange Factors* / metabolism Myosin Type II* / metabolism Neural Stem Cells* / cytology Neural Stem Cells* / metabolism Phosphatidylinositol Phosphates / metabolism |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |