論文 - 詳細
| RRC ID | 83833 |
|---|---|
| 著者 | Pan YK, Perry SF. |
| タイトル | Developing zebrafish utilize taste-signaling pathways for oxygen chemoreception. |
| ジャーナル | Curr Biol |
| Abstract |
A fundamental requirement for all animals is to sense and respond to changes in environmental O2 availability. Low O2 (hypoxia) typically stimulates breathing, a universal and critical response termed the hypoxic ventilatory response (HVR). In this study, we test the hypothesis that taste-signaling pathways are used for O2 sensing and activation of the HVR. We show that Merkel-like cells (MLCs), which are part of the taste-bud complex, function as O2 chemoreceptor cells in larval zebrafish and that transduction of the O2 signal uses taste-signaling pathways. Specifically, MLCs responded to hypoxia in vivo with an increase in Ca2+ activity that can drive the HVR. In addition, MLCs transmit O2 signals to afferent cranial nerves IX and X (nIX/X), which project into the area postrema within the hindbrain and synapse with interneurons that are in contact with vagal motor neurons. Hypoxia or chemo-activation of nIX/X caused Ca2+ activity to increase within the area postrema and elicited hyperventilation. The results provide the first demonstration of an O2 signaling pathway that commences with the activation of taste receptors (MLCs) to yield a critical physiological reflex, the HVR. |
| 巻・号 | 34(18) |
| ページ | 4272-4284.e5 |
| 公開日 | 2024-9-23 |
| DOI | 10.1016/j.cub.2024.08.015 |
| PII | S0960-9822(24)01127-8 |
| PMID | 39260364 |
| MeSH | Animals Chemoreceptor Cells* / metabolism Hypoxia / metabolism Larva / metabolism Larva / physiology Oxygen* / metabolism Signal Transduction* Taste* / physiology Taste Buds / metabolism Taste Buds / physiology Zebrafish* |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(CM-isl1:GFP)rw0 |