Reference - Detail
| RRC ID | 83836 |
|---|---|
| Author | Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N. |
| Title | Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish. |
| Journal | Dev Cell |
| Abstract |
Cells functioning at a specific zone by clustering according to gene expression are recognized as zonated cells. Here, we demonstrate anatomical and functional zones in the zebrafish heart. The cardiomyocytes (CMs) at the atrioventricular canal between the atrium and ventricle could be grouped into three zones according to the localization of signal-activated CMs: Wnt/β-catenin signal+, Bmp signal+, and Tbx2b+ zones. Endocardial endothelial cells (ECs) changed their characteristics, penetrated the Wnt/β-catenin signal+ CM zone, and became coronary ECs covering the heart. Coronary vessel length was reduced when the Wnt/β-catenin signal+ CMs were depleted. Collectively, we demonstrate the importance of anatomical and functional zonation of CMs in the zebrafish heart. |
| Volume | 60(1) |
| Pages | 21-29.e8 |
| Published | 2025-1-6 |
| DOI | 10.1016/j.devcel.2024.09.012 |
| PII | S1534-5807(24)00540-9 |
| PMID | 39395410 |
| MeSH | Animals Coronary Vessels* / cytology Coronary Vessels* / embryology Coronary Vessels* / metabolism Endothelial Cells / cytology Endothelial Cells / metabolism Gene Expression Regulation, Developmental Heart Atria / cytology Heart Atria / embryology Heart Atria / metabolism Myocytes, Cardiac* / cytology Myocytes, Cardiac* / metabolism Wnt Signaling Pathway* Zebrafish* / embryology Zebrafish* / metabolism Zebrafish Proteins* / genetics Zebrafish Proteins* / metabolism beta Catenin* / metabolism |
| IF | 10.092 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | Tg(UAS:EGFP) |