| RRC ID |
83937
|
| Author |
Yamane K, Yamaguchi K, Teruya Y, Miyake N, Nakayama Y, Nonaka T, Chikumi H, Yamasaki A.
|
| Title |
ULBP2 Promotes Tumor Progression by Suppressing NKG2D-Mediated Anti-Tumor Immunity.
|
| Journal |
Int J Mol Sci
|
| Abstract |
UL-16 binding protein 2 (ULBP2), a human NKG2D ligand, has been identified as a poor prognostic factor in several cancers based on recent comprehensive analyses of immune-related genes using the Cancer Genome Atlas datasets. Despite its clinical significance, the functional role of ULBP2 in vivo remains largely unknown. In this study, we investigated the role of ULBP2 in modulating anti-tumor immunity using murine melanoma cell lines engineered to stably express surface-expressed or soluble ULBP2. Subcutaneous transplantation of ULBP2-expressing melanoma cells into syngeneic mice resulted in accelerated tumor growth, mediated by surface-expressed ULBP2, through the suppression of NKG2D-dependent immune responses. In vitro experiments revealed that sustained exposure to tumor-expressed ULBP2 reduced NKG2D expression and cytotoxic activity of splenocytes. In contrast, soluble ULBP2 did not significantly affect tumor growth or immune responses. These findings suggest that surface-expressed ULBP2 plays a pivotal role in tumor immune evasion and highlight its potential as a therapeutic target to enhance anti-tumor immunity.
|
| Volume |
26(7)
|
| Published |
2025-3-24
|
| DOI |
10.3390/ijms26072950
|
| PII |
ijms26072950
|
| PMID |
40243581
|
| PMC |
PMC11988498
|
| MeSH |
Animals
Cell Line, Tumor
Disease Progression
GPI-Linked Proteins
Humans
Intercellular Signaling Peptides and Proteins* / genetics
Intercellular Signaling Peptides and Proteins* / metabolism
Melanoma* / immunology
Melanoma* / metabolism
Melanoma* / pathology
Mice
Mice, Inbred C57BL
NK Cell Lectin-Like Receptor Subfamily K* / genetics
NK Cell Lectin-Like Receptor Subfamily K* / immunology
NK Cell Lectin-Like Receptor Subfamily K* / metabolism
|
| IF |
4.556
|
| Resource |
| Human and Animal Cells |
B16F10(RCB2630)
B16/BL6(RCB2638)
YAC-1(RCB2799)
LLC(RCB0558) |
