論文 - 詳細
| RRC ID | 83942 |
|---|---|
| 著者 | Aoki S, Hori M, Zhang H, Tsujioka H, Yamashita T. |
| タイトル | Comparison of Spinal Cord Regeneration Capacity in Zebrafish and Medaka. |
| ジャーナル | Neurochem Res |
| Abstract |
In mammals, spinal cord injury often results in permanent impairment of motor function owing to ineffective tissue regeneration. Unlike mammals, zebrafish have the remarkable ability to regenerate many tissues, including the spinal cord. Cross-species comparison is an attractive approach for revealing regeneration-specific mechanisms, but the large evolutionary distance between species sometimes hinders direct comparison. Recent studies have revealed that another model fish species, medaka, has a low regenerative ability in some tissues, making comparisons with them advantageous to revealing regeneration-specific mechanisms. However, their spinal cord regenerative ability has not been compared to other models. In this study, we functionally and histologically compared the spinal cord regeneration abilities of zebrafish and medaka. Swimming speed recovery was significantly lower in medaka than in zebrafish. Bridging of glia and neural tissue were thinner in medaka than in zebrafish. Axonal extension across the injured site was observed in zebrafish but not in medaka. Comparison of their gene expression profiles revealed genes involved in "Regeneration" were upregulated in zebrafish, whereas genes related to "Synaptic signaling" were downregulated in medaka. These results suggest that the ability to regenerate the spinal cord is lower in medaka than in zebrafish, making medaka an attractive model for revealing the mechanisms of spinal cord regeneration. |
| 巻・号 | 50(3) |
| ページ | 153 |
| 公開日 | 2025-4-25 |
| DOI | 10.1007/s11064-025-04389-9 |
| PII | 10.1007/s11064-025-04389-9 |
| PMID | 40278963 |
| PMC | PMC12031921 |
| MeSH | Animals Nerve Regeneration* / physiology Oryzias* / physiology Recovery of Function / physiology Spinal Cord* / physiology Spinal Cord Injuries* / pathology Spinal Cord Injuries* / physiopathology Spinal Cord Regeneration* / physiology Zebrafish* / physiology |
| IF | 3.038 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | OK-Cab |