Reference - Detail
| RRC ID | 83956 |
|---|---|
| Author | Uehara SK, Nishiike Y, Maeda K, Karigo T, Kuraku S, Okubo K, Kanda S. |
| Title | Identification of the FSH-RH as the other gonadotropin-releasing hormone. |
| Journal | Nat Commun |
| Abstract |
In vertebrates, folliculogenesis and ovulation are regulated by two distinct pituitary gonadotropins: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Currently, there is an intriguing consensus that a single hypothalamic neurohormone, gonadotropin-releasing hormone (GnRH), regulates the secretion of both FSH and LH, although the required timing and functions of FSH and LH are different. However, recent studies in many non-mammalian vertebrates indicated that GnRH is dispensable for FSH function. Here, by using medaka as a model teleost, we successfully identify cholecystokinin as the other gonadotropin regulator, FSH-releasing hormone (FSH-RH). Our histological and in vitro analyses demonstrate that hypothalamic cholecystokinin-expressing neurons directly affect FSH cells through the cholecystokinin receptor, Cck2rb, thereby increasing the expression and release of FSH. Remarkably, the knockout of this pathway minimizes FSH expression and results in a failure of folliculogenesis. Here, we propose the existence of the "dual GnRH model" in vertebrates that utilize both FSH-RH and LH-RH. |
| Volume | 15(1) |
| Pages | 5342 |
| Published | 2024-6-27 |
| DOI | 10.1038/s41467-024-49564-8 |
| PII | 10.1038/s41467-024-49564-8 |
| PMID | 38937445 |
| PMC | PMC11211334 |
| MeSH | Animals Female Follicle Stimulating Hormone* / genetics Follicle Stimulating Hormone* / metabolism Gonadotropin-Releasing Hormone* / genetics Gonadotropin-Releasing Hormone* / metabolism Hypothalamus* / metabolism Luteinizing Hormone / metabolism Neurons / metabolism Oryzias* / genetics Oryzias* / metabolism Ovarian Follicle / metabolism Ovulation / genetics |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 30 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Medaka | Kiyosu |