| RRC ID |
83959
|
| 著者 |
Marquina-Solis J, Feng L, Vandewyer E, Beets I, Hawk J, Colón-Ramos DA, Yu J, Fox BW, Schroeder FC, Bargmann CI.
|
| タイトル |
Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance.
|
| ジャーナル |
Cell Rep
|
| Abstract |
Pathogenic infection elicits behaviors that promote recovery and survival of the host. After exposure to the pathogenic bacterium Pseudomonas aeruginosa PA14, the nematode Caenorhabditis elegans modifies its sensory preferences to avoid the pathogen. Here, we identify antagonistic neuromodulators that shape this acquired avoidance behavior. Using an unbiased cell-directed neuropeptide screen, we show that AVK neurons upregulate and release RF/RYamide FLP-1 neuropeptides during infection to drive pathogen avoidance. Manipulations that increase or decrease AVK activity accelerate or delay pathogen avoidance, respectively, implicating AVK in the dynamics of avoidance behavior. FLP-1 neuropeptides drive pathogen avoidance through the G protein-coupled receptor DMSR-7, as well as other receptors. DMSR-7 in turn acts in multiple neurons, including tyraminergic/octopaminergic neurons that receive convergent avoidance signals from the cytokine DAF-7/transforming growth factor β. Neuromodulators shape pathogen avoidance through multiple mechanisms and targets, in agreement with the distributed neuromodulatory connectome of C. elegans.
|
| 巻・号 |
43(4)
|
| ページ |
114042
|
| 公開日 |
2024-4-23
|
| DOI |
10.1016/j.celrep.2024.114042
|
| PII |
S2211-1247(24)00370-X
|
| PMID |
38573858
|
| PMC |
PMC11063628
|
| MeSH |
Animals
Avoidance Learning / physiology
Biogenic Monoamines / metabolism
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans* / microbiology
Caenorhabditis elegans Proteins* / metabolism
Neurons / metabolism
Neuropeptides* / metabolism
Pseudomonas aeruginosa* / metabolism
Receptors, G-Protein-Coupled / metabolism
Signal Transduction
|
| リソース情報 |
| 線虫 |
tm1497 |
