論文 - 詳細
| RRC ID | 83964 |
|---|---|
| 著者 | Vergani-Junior CA, Moro RP, Pinto S, De-Souza EA, Camara H, Braga DL, Tonon-da-Silva G, Knittel TL, Ruiz GP, Ludwig RG, Massirer KB, Mair WB, Mori MA. |
| タイトル | An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress. |
| ジャーナル | Nat Commun |
| Abstract |
Cellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C. elegans ortholog of human AGO2, plays an essential role in microRNA processing and function. Here we investigated the mechanisms governing ALG-1 expression in C. elegans and the players controlling lifespan and stress resistance downstream of ALG-1. We show that upregulation of ALG-1 is a shared feature in conditions linked to increased longevity (e.g., germline-deficient glp-1 mutants). ALG-1 knockdown reduces lifespan and oxidative stress resistance, while overexpression enhances survival against pro-oxidant agents but not heat or reductive stress. R02D3.7 represses alg-1 expression, impacting oxidative stress resistance at least in part via ALG-1. microRNAs upregulated in glp-1 mutants (miR-87-3p, miR-230-3p, and miR-235-3p) can target genes in the protein disulfide isomerase pathway and protect against oxidative stress. This study unveils a tightly regulated network involving transcription factors and microRNAs which controls organisms' ability to withstand oxidative stress. |
| 巻・号 | 15(1) |
| ページ | 3070 |
| 公開日 | 2024-4-9 |
| DOI | 10.1038/s41467-024-47306-4 |
| PII | 10.1038/s41467-024-47306-4 |
| PMID | 38594249 |
| PMC | PMC11003958 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / metabolism Glucagon-Like Peptide 1 / metabolism Humans MicroRNAs* / genetics MicroRNAs* / metabolism Oxidative Stress / genetics RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm689 |