| RRC ID |
83964
|
| 著者 |
Vergani-Junior CA, Moro RP, Pinto S, De-Souza EA, Camara H, Braga DL, Tonon-da-Silva G, Knittel TL, Ruiz GP, Ludwig RG, Massirer KB, Mair WB, Mori MA.
|
| タイトル |
An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Cellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C. elegans ortholog of human AGO2, plays an essential role in microRNA processing and function. Here we investigated the mechanisms governing ALG-1 expression in C. elegans and the players controlling lifespan and stress resistance downstream of ALG-1. We show that upregulation of ALG-1 is a shared feature in conditions linked to increased longevity (e.g., germline-deficient glp-1 mutants). ALG-1 knockdown reduces lifespan and oxidative stress resistance, while overexpression enhances survival against pro-oxidant agents but not heat or reductive stress. R02D3.7 represses alg-1 expression, impacting oxidative stress resistance at least in part via ALG-1. microRNAs upregulated in glp-1 mutants (miR-87-3p, miR-230-3p, and miR-235-3p) can target genes in the protein disulfide isomerase pathway and protect against oxidative stress. This study unveils a tightly regulated network involving transcription factors and microRNAs which controls organisms' ability to withstand oxidative stress.
|
| 巻・号 |
15(1)
|
| ページ |
3070
|
| 公開日 |
2024-4-9
|
| DOI |
10.1038/s41467-024-47306-4
|
| PII |
10.1038/s41467-024-47306-4
|
| PMID |
38594249
|
| PMC |
PMC11003958
|
| MeSH |
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins* / metabolism
Glucagon-Like Peptide 1 / metabolism
Humans
MicroRNAs* / genetics
MicroRNAs* / metabolism
Oxidative Stress / genetics
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism
|
| リソース情報 |
| 線虫 |
tm689 |
