論文 - 詳細
| RRC ID | 83971 |
|---|---|
| 著者 | Martin CG, Bent JS, Hill T, Topalidou I, Singhvi A. |
| タイトル | Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans. |
| ジャーナル | Dev Cell |
| Abstract |
For an organ to maintain correct architecture and function, its diverse cellular components must coordinate their size and shape. Although cell-intrinsic mechanisms driving homotypic cell-cell coordination are known, it is unclear how cell shape is regulated across heterotypic cells. We find that epithelial cells maintain the shape of neighboring sense-organ glia-neuron units in adult Caenorhabditis elegans (C. elegans). Hsp co-chaperone UNC-23/BAG2 prevents epithelial cell shape from deforming, and its loss causes head epithelia to stretch aberrantly during animal movement. In the sense-organ glia, amphid sheath (AMsh), this causes progressive fibroblast growth factor receptor (FGFR)-dependent disruption of the glial apical cytoskeleton. Resultant glial cell shape alteration causes concomitant shape change in glia-associated neuron endings. Epithelial UNC-23 maintenance of glia-neuron shape is specific both spatially, within a defined anatomical zone, and temporally, in a developmentally critical period. As all molecular components uncovered are broadly conserved across central and peripheral nervous systems, we posit that epithelia may similarly regulate glia-neuron architecture cross-species. |
| 巻・号 | 59(13) |
| ページ | 1668-1688.e7 |
| 公開日 | 2024-7-8 |
| DOI | 10.1016/j.devcel.2024.04.005 |
| PII | S1534-5807(24)00230-2 |
| PMID | 38670103 |
| PMC | PMC11233253 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Shape Cytoskeleton / metabolism Epithelial Cells / cytology Epithelial Cells / metabolism Neuroglia* / metabolism Neurons* / metabolism Receptors, Fibroblast Growth Factor / genetics Receptors, Fibroblast Growth Factor / metabolism Stress, Mechanical |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2318 tm832 tm544 |