| RRC ID |
83973
|
| Author |
Harders RH, Morthorst TH, Landgrebe LE, Lande AD, Fuglsang MS, Mortensen SB, Feteira-Montero V, Jensen HH, Wesseltoft JB, Olsen A.
|
| Title |
CED-6/GULP and components of the clathrin-mediated endocytosis machinery act redundantly to correctly display CED-1 on the cell membrane in Caenorhabditis elegans.
|
| Journal |
G3 (Bethesda)
|
| Abstract |
CED-1 (cell death abnormal) is a transmembrane receptor involved in the recognition of "eat-me" signals displayed on the surface of apoptotic cells and thus central for the subsequent engulfment of the cell corpse in Caenorhabditis elegans. The roles of CED-1 in engulfment are well established, as are its downstream effectors. The latter include the adapter protein CED-6/GULP and the ATP-binding cassette family homolog CED-7. However, how CED-1 is maintained on the plasma membrane in the absence of engulfment is currently unknown. Here, we show that CED-6 and CED-7 have a novel role in maintaining CED-1 correctly on the plasma membrane. We propose that the underlying mechanism is via endocytosis as CED-6 and CED-7 act redundantly with clathrin and its adaptor, the Adaptor protein 2 complex, in ensuring correct CED-1 localization. In conclusion, CED-6 and CED-7 impact other cellular processes than engulfment of apoptotic cells.
|
| Volume |
14(7)
|
| Published |
2024-7-8
|
| DOI |
10.1093/g3journal/jkae088
|
| PII |
7663352
|
| PMID |
38696649
|
| PMC |
PMC11228867
|
| MeSH |
ATP-Binding Cassette Transporters / genetics
ATP-Binding Cassette Transporters / metabolism
Adaptor Protein Complex 2 / metabolism
Animals
Apoptosis
Apoptosis Regulatory Proteins
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Cell Membrane* / metabolism
Clathrin* / metabolism
Endocytosis*
Membrane Proteins / genetics
Membrane Proteins / metabolism
Protein Transport
|
| Resource |
| C.elegans |
tm1826 |
