| RRC ID |
83981
|
| Author |
Nakayama A, Watanabe M, Yamashiro R, Kuroyanagi H, Matsuyama HJ, Oshima A, Mori I, Nakano S.
|
| Title |
A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans.
|
| Journal |
Proc Natl Acad Sci U S A
|
| Abstract |
While depolarization of the neuronal membrane is known to evoke the neurotransmitter release from synaptic vesicles, hyperpolarization is regarded as a resting state of chemical neurotransmission. Here, we report that hyperpolarizing neurons can actively signal neural information by employing undocked hemichannels. We show that UNC-7, a member of the innexin family in Caenorhabditis elegans, functions as a hemichannel in thermosensory neurons and transmits temperature information from the thermosensory neurons to their postsynaptic interneurons. By monitoring neural activities in freely behaving animals, we find that hyperpolarizing thermosensory neurons inhibit the activity of the interneurons and that UNC-7 hemichannels regulate this process. UNC-7 is required to control thermotaxis behavior and functions independently of synaptic vesicle exocytosis. Our findings suggest that innexin hemichannels mediate neurotransmission from hyperpolarizing neurons in a manner that is distinct from the synaptic transmission, expanding the way of neural circuitry operations.
|
| Volume |
121(21)
|
| Pages |
e2406565121
|
| Published |
2024-5-21
|
| DOI |
10.1073/pnas.2406565121
|
| PMID |
38753507
|
| PMC |
PMC11127054
|
| MeSH |
Animals
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Connexins / genetics
Connexins / metabolism
Interneurons / metabolism
Membrane Proteins
Neurons* / metabolism
Synaptic Transmission* / physiology
Synaptic Vesicles / metabolism
Taxis Response / physiology
|
| Resource |
| C.elegans |
tm1896
tm3524
tm5027
tm4886
tm3485
tm10647
tm14359
tm1983
tm2569
tm2984
tm3886
tm790
tm11713
tm5180
tm10648
tm4639
tm1875
tm5158
tm6467
tm3023 |
