論文 - 詳細
| RRC ID | 84005 |
|---|---|
| 著者 | Lee H, Boor SA, Hilbert ZA, Meisel JD, Park J, Wang Y, McKeown R, Fischer SEJ, Andersen EC, Kim DH. |
| タイトル | Genetic variants that modify neuroendocrine gene expression and foraging behavior of C. elegans. |
| ジャーナル | Sci Adv |
| Abstract |
The molecular mechanisms underlying diversity in animal behavior are not well understood. A major experimental challenge is determining the contribution of genetic variants that affect neuronal gene expression to differences in behavioral traits. In Caenorhabditis elegans, the neuroendocrine transforming growth factor-β ligand, DAF-7, regulates diverse behavioral responses to bacterial food and pathogens. The dynamic neuron-specific expression of daf-7 is modulated by environmental and endogenous bacteria-derived cues. Here, we investigated natural variation in the expression of daf-7 from the ASJ pair of chemosensory neurons. We identified common genetic variants in gap-2, encoding a Ras guanosine triphosphatase (GTPase)-activating protein homologous to mammalian synaptic Ras GTPase-activating protein, which modify daf-7 expression cell nonautonomously and promote exploratory foraging behavior in a partially DAF-7-dependent manner. Our data connect natural variation in neuron-specific gene expression to differences in behavior and suggest that genetic variation in neuroendocrine signaling pathways mediating host-microbe interactions may give rise to diversity in animal behavior. |
| 巻・号 | 10(24) |
| ページ | eadk9481 |
| 公開日 | 2024-6-14 |
| DOI | 10.1126/sciadv.adk9481 |
| PMID | 38865452 |
| PMC | PMC11168454 |
| MeSH | Animals Behavior, Animal / physiology Caenorhabditis elegans* / genetics Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Feeding Behavior Gene Expression Regulation Genetic Variation* Neurons / metabolism Neurosecretory Systems / metabolism Signal Transduction Transforming Growth Factor beta |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm748 |