| RRC ID |
84005
|
| 著者 |
Lee H, Boor SA, Hilbert ZA, Meisel JD, Park J, Wang Y, McKeown R, Fischer SEJ, Andersen EC, Kim DH.
|
| タイトル |
Genetic variants that modify neuroendocrine gene expression and foraging behavior of C. elegans.
|
| ジャーナル |
Sci Adv
|
| Abstract |
The molecular mechanisms underlying diversity in animal behavior are not well understood. A major experimental challenge is determining the contribution of genetic variants that affect neuronal gene expression to differences in behavioral traits. In Caenorhabditis elegans, the neuroendocrine transforming growth factor-β ligand, DAF-7, regulates diverse behavioral responses to bacterial food and pathogens. The dynamic neuron-specific expression of daf-7 is modulated by environmental and endogenous bacteria-derived cues. Here, we investigated natural variation in the expression of daf-7 from the ASJ pair of chemosensory neurons. We identified common genetic variants in gap-2, encoding a Ras guanosine triphosphatase (GTPase)-activating protein homologous to mammalian synaptic Ras GTPase-activating protein, which modify daf-7 expression cell nonautonomously and promote exploratory foraging behavior in a partially DAF-7-dependent manner. Our data connect natural variation in neuron-specific gene expression to differences in behavior and suggest that genetic variation in neuroendocrine signaling pathways mediating host-microbe interactions may give rise to diversity in animal behavior.
|
| 巻・号 |
10(24)
|
| ページ |
eadk9481
|
| 公開日 |
2024-6-14
|
| DOI |
10.1126/sciadv.adk9481
|
| PMID |
38865452
|
| PMC |
PMC11168454
|
| MeSH |
Animals
Behavior, Animal / physiology
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / physiology
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Feeding Behavior
Gene Expression Regulation
Genetic Variation*
Neurons / metabolism
Neurosecretory Systems / metabolism
Signal Transduction
Transforming Growth Factor beta
|
| リソース情報 |
| 線虫 |
tm748 |
