Reference - Detail
| RRC ID | 84053 |
|---|---|
| Author | Saito TT, Yamamoto K, Minami H, Tsujiue T. |
| Title | Caenorhabditis elegans brc-1 mutation increases the number of COSA-1 foci in him-8 and zim-2 mutants. |
| Journal | MicroPubl Biol |
| Abstract |
Crossover designation factors such as COSA-1 are concentrated at the specific DNA double-strand break (DSB) sites to promote crossover formation. zim-1 mutants, which show defects in the homologous chromosome pairing of chromosomes II and III, increase the COSA-1 foci/normal bivalent state compared to the expected value. The excess designation was suppressed by an additional mutation in brc-1 in zim-1 mutants. We demonstrated that the number of COSA-1 foci in him-8 and zim-2 mutants, showing defects in the pairing of the X and V chromosomes, respectively, increased compared to the expected value, and brc-1 mutation accelerated the number of COSA-1 foci in oogenesis. |
| Volume | 2024 |
| Published | 2024-1-1 |
| DOI | 10.17912/micropub.biology.001077 |
| PMID | 39132054 |
| PMC | PMC11310775 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1145 tm611 tm574 |