Reference - Detail
| RRC ID | 84079 |
|---|---|
| Author | Buyannemekh K, Villoutreix P, Bertrand V. |
| Title | Left/right asymmetrically expressed ephrin and Flamingo proteins regulate lateralized axon growth in C. elegans. |
| Journal | Dev Biol |
| Abstract |
While the nervous system of bilaterian animals is mainly left-right (L-R) symmetric at the anatomical level, some molecular and functional L-R asymmetries exist. However, the extent of these molecular asymmetries and their functional consequences remain poorly characterized. C. elegans allows to study L-R asymmetries in the nervous system with single-neuron resolution. We have previously shown that a neural bHLH transcription factor, HLH-16/Olig, is L-R asymmetrically expressed in the AIY neuron lineage and regulates AIY axon projections in a L-R asymmetric manner. Here, by combining a candidate approach and single-cell RNA sequencing data analysis, we identify the ephrin protein EFN-2 and the Flamingo protein FMI-1 as downstream targets of HLH-16 that are L-R asymmetrically expressed in the AIY lineage. We show that EFN-2 and FMI-1 collaborate in the L-R asymmetric regulation of axonal growth. EFN-2 may act via a non-canonical receptor of the L1CAM family, SAX-7. Our study reveals novel molecular L-R asymmetries in the C. elegans nervous system and their functional consequences. |
| Volume | 517 |
| Pages | 117-125 |
| Published | 2025-1-1 |
| DOI | 10.1016/j.ydbio.2024.09.014 |
| PII | S0012-1606(24)00241-0 |
| PMID | 39341445 |
| MeSH | Animals Axons* / metabolism Basic Helix-Loop-Helix Transcription Factors / genetics Basic Helix-Loop-Helix Transcription Factors / metabolism Body Patterning / genetics Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Ephrins* / genetics Ephrins* / metabolism Gene Expression Regulation, Developmental Neural Cell Adhesion Molecules Neurons / metabolism |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm3056 |