論文 - 詳細
| RRC ID | 84111 |
|---|---|
| 著者 | Cowen MH, Haskell D, Zoga K, Reddy KC, Chalasani SH, Hart MP. |
| タイトル | Conserved autism-associated genes tune social feeding behavior in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Animal foraging is an essential and evolutionarily conserved behavior that occurs in social and solitary contexts, but the underlying molecular pathways are not well defined. We discover that conserved autism-associated genes (NRXN1(nrx-1), NLGN3(nlg-1), GRIA1,2,3(glr-1), GRIA2(glr-2), and GLRA2,GABRA3(avr-15)) regulate aggregate feeding in C. elegans, a simple social behavior. NRX-1 functions in chemosensory neurons (ADL and ASH) independently of its postsynaptic partner NLG-1 to regulate social feeding. Glutamate from these neurons is also crucial for aggregate feeding, acting independently of NRX-1 and NLG-1. Compared to solitary counterparts, social animals show faster presynaptic release and more presynaptic release sites in ASH neurons, with only the latter requiring nrx-1. Disruption of these distinct signaling components additively converts behavior from social to solitary. Collectively, we find that aggregate feeding is tuned by conserved autism-associated genes through complementary synaptic mechanisms, revealing molecular principles driving social feeding. |
| 巻・号 | 15(1) |
| ページ | 9301 |
| 公開日 | 2024-10-28 |
| DOI | 10.1038/s41467-024-53590-x |
| PII | 10.1038/s41467-024-53590-x |
| PMID | 39468047 |
| PMC | PMC11519495 |
| MeSH | Animals Autistic Disorder* / genetics Caenorhabditis elegans* / genetics Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Adhesion Molecules, Neuronal Chemoreceptor Cells / metabolism Feeding Behavior* / physiology Glutamic Acid / metabolism Neural Cell Adhesion Molecules / genetics Neural Cell Adhesion Molecules / metabolism Receptors, AMPA / genetics Receptors, AMPA / metabolism Social Behavior* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 41 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.7 |
| リソース情報 | |
| 線虫 | tm1811 |